2021 Fiscal Year Final Research Report

Elucidation of the onset mechanism of chronic fatigue mediated by herpes virus and search for its regulator

Research Project

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Project/Area Number	19K11750
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	Nihon Pharmaceutical University
Principal Investigator	Inoue Hiroko 日本薬科大学, 薬学部, 教授 (50367306)
Co-Investigator(Kenkyū-buntansha)	松本直行鶴見大学, 歯学部, 准教授 (20386080) 岡田直子日本薬科大学, 薬学部, 講師 (50636165) 中山亮子鶴見大学, 歯学部, 助教 (50749843) 斎藤一郎鶴見大学, 歯学部, 教授 (60147634) 山崎智恵鶴見大学, 歯学部, 学部助手 (80817122)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	Epstein-Barr virus / fatique / レスベラトロール
Outline of Final Research Achievements	As a result of investigating the genetically modified mice using the transcriptional activation of the BZLF-1 gene, which is an index of Epstein-Barr virus (EB virus) reactivation, the EB virus reactivets in some tissues with aging. It was confirmed that activation was easily induced. Furthermore, in the highly active brain, it is speculated that some humoral factor reactivates the EB virus, which may be involved in the development of chronic fatigue and multiple sclerosis in EB virus-infected individuals. In addition, since resveratrol suppresses the reactivation of EB virus in vitro, we found that resveratrol may act prophylactically on various diseases related to EB reactivation.
Free Research Field	抗加齢医学
Academic Significance and Societal Importance of the Research Achievements	Epstein-Barr ウイルス（EBウイルス）は何らかの原因で再活性化されると多発性硬化症を初めとする自己免疫疾患、慢性疲労症候群の発症と関連がある。今回の研究結果より、加齢とともにEBウイルスは再活性化されやすくなり、特に脳における活性が高く、またレスベラトロールよりその活性を抑制することが明らかとなった。EBウイルス関連の慢性疲労症候群がレスベラトロールなどの食因子で制御できることは、健康増進の意味から有意義な研究成果であると考える。