Development of Nuclear Medicine Imaging Techniques for Personalized Medicine Focusing on Metabolic Changes in Glioblastoma

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K17164
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: Koyasu Sho 京都大学, 医学研究科, 助教 (80781913)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 膠芽腫 / IDH / 核医学 / 変異 / 酢酸

Outline of Final Research Achievements

Glioblastoma is an intracranial malignancy with an extremely poor prognosis. Recently, isocitrate dehydrogenase (IDH) mutations have led to the classification of glioblastoma into two major groups with very different biological characteristics and prognoses. In this study, we compared changes in 14C-acetate uptake in tumor cell models (glioblastoma cell line and HPV-associated cervical cancer cell line) and in xenograft mice model. In tumor sections, the distribution of 14C-acetic acid was found to be relatively homogeneous. These results indicates the possibility of a new in vivo imaging method to evaluate IDH mutations.

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Free Research Field

画像診断学

Academic Significance and Societal Importance of the Research Achievements

膠芽腫におけるIDH変異は重要な予後因子であることがわかっているがその評価は腫瘍を採取してくる必要があり、これまで非侵襲的な術前診断方法はまだ確立されたものがなかった。今回の研究で、標識した酢酸を用いることでその代謝変化をとらえ、集積量の差として遺伝子変異を可視化できる可能性が示された。これはすなわち直接的に細胞を採取することなく画像技術によって遺伝子変化を診断できる可能性が示された。