Functional analysis for regulatory systems of focal microbiota activity in preterm labor

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K18714
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Fukuoka University
• Principal Investigator: Kohei Miyata 福岡大学, 医学部, 准教授 (80759233)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: クオラムセンシング / 早産 / 細菌叢

Outline of Final Research Achievements

Preterm birth is a most affective event for the newborn prognosis. In this study, we focused on the relation ship between Labor or uterine contraction and vaginal bioactive substance, Higher concentration of AI-2 was detected in the pregnant who were in labor. Several factors were analyzed to clarified how the AI-2 affected to the uterine contraction. However there were no relation between AI-2 and inflammation status or cervical status, the frequency of uterine contraction was the only correlated to AI-2 concentration. These findings suggested thatonset of labor was promoted by bioactive substance, AI-2.

Free Research Field

周産期医学

Academic Significance and Societal Importance of the Research Achievements

この研究は早産の予測および治療に役立てられる可能性があります。
近年早産児の予後は改善していますが、これは新生児期の医療の発展によるののであり、妊娠中の早産の予防や早産の治療などの、妊婦に対する医療は改善していません。このため、早産および切迫早産の新たな医学的知見の探索ならびに予防法・治療方法の開発が求められています。本研究の結果は今後の早産児の予後を改善するため礎となります。