Research on the effects of voluntary exercise intervention in Regenerative Medicine for Spinal Cord Injury

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K19814
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Aino University
• Principal Investigator: Tsukagoshi Chihiro 藍野大学, 医療保健学部, 講師 (20782478)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 脊髄損傷モデル動物 / リハビリテーション / 再生医療

Outline of Final Research Achievements

To investigate the evidence for the recovery of motor function by combining regenerative medicine and rehabilitation, we divided thoracic spinal cord injury model rats into a treadmill group, a theme park group, and a control group and compared. As a result, BBB scores were better than in both exercise groups than in the control group. In addition, comparing the distribution of the β-Tubulin and GAP43, the distribution of GAP43 in the injured parts were lager in the both exercise groups than in the control group. Now we are searching for rehabilitative training that enhances the effect of spinal cord regeneration treatment and intend to further verify its effect.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

再生医療とリハビリテーションの併用は、永続的に後遺症に苦しむ脊髄損傷患にとってたいへん期待されており、また、リハビリテーション職種にとって新しいリハビリテーション手法を開発していくうえで、研究成果を発信していくことはたいへん意義がある。本研究は、脊髄損傷モデルラットに対して、自発的運動と強制的運動という2種類の運動介入を行い、対照群と比べて、どちらも一定の効果がある可能性を示唆した点で新しい。今後、細胞移植や液性因子を介した脊髄再生治療を試み、その効果を増強する運動介入を行い、詳細な運動機能評価および免疫組織学的評価、有効因子など総合的に検証したい。