Functional shifts and neural representations between striatal subregions during sensory-motor learning

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K20074
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59030:Physical education, and physical and health education-related
• Research Institution: Osaka City University (2021); Dokkyo Medical University (2020); Fukushima Medical University (2019)
• Principal Investigator: Setogawa Susumu 大阪市立大学, 大学院医学研究科, 特任助教 (30760508)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 大脳基底核 / 線条体 / 手続き記憶 / 知覚運動学習

Outline of Final Research Achievements

In our previous study, we showed that anterior and posterior striatal regions are involved during sensorimotor learning. In this study, we used pharmacological experiments to identify the causal relationship between the anterior/posterior regions which was previously identified by the small animal neuroimaging techniques and the function for sensorimotor learning. In addition, we used multi-unit recordings to examine differences in information processing between the two striatal regions during the learning. We found that the anterior striatum has more neuron types that represent behavioral outcomes, whereas the posterior striatum has a greater proportion of neuron types with information related to stimulus-response responses.

Free Research Field

スポーツ科学

Academic Significance and Societal Importance of the Research Achievements

先行研究では、線条体の前方部における可塑性が知覚運動学習において重要な役割を果たしていると考えられてきた。一方、本研究では、線条体の前部と後部が知覚運動学習の異なる学習段階において機能することが重要であることを新たに発見した。この成果は、大脳基底核における学習メカニズムの更なる理解に貢献する。