Study for next-generation precision medicine based on the highly targeted theranostics for the pathological neovascularization of cancers

2023 Fiscal Year Final Research Report

• Project/Area Number: 19KK0369
• Research Category: Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: National Institutes for Quantum Science and Technology
• Principal Investigator: Takakusagi Yoichi 国立研究開発法人量子科学技術研究開発機構, 量子生命科学研究所, 上席研究員 (60439916)
• Project Period (FY): 2020 – 2023
• Keywords: 超偏極 / 動的核偏極 / 核磁気共鳴 / 放射線増感剤 / がん / 血管新生 / 個別化医療

Outline of Final Research Achievements

This research aimed as an international collaborative research for the establishment of a highly cancer precision medicine that targets pathological neovascularization of cancers by means of hyperpolarized nuclear magnetic resonance imaging (HP-MRI) combined use with a new chemoradiotherapy. Using an HP-MRI metabolic diagnostic sensor that predicts cancer angiogenesis and metastasis, and a new radiosensitizer that inhibits cancer angiogenesis, we have conducted a model experiment for cancer theranostics at a facility that equips a (pre)clinical hyperpolarizer with the highest performance, which had not been domestically installed then. Thus, we have demonstrated the possibility of a new cancer precision medicine that may potentially solve problems in conventional cancer diagnosis and treatment, and accelerated the establishment of an experimental basis for further practical development.

Free Research Field

生体医工学

Academic Significance and Societal Importance of the Research Achievements

従来のがん診断治療における問題点を一掃し、新しい角度からのがん個別化医療の確立と実用化開発を加速し、がん医療の高度化へと貢献する可能性を秘めている。また、世界的に大幅な遅れを取っている HP-MRI の国内研究拠点の形成や、がん以外の疾患診断への応用拡張、量子操作技術である HP-MRI を 基盤とした新たな学術分野の開拓など、その普及促進にも貢献する。