2009 Fiscal Year Final Research Report
Oxidative stress-induced tumorigenesis in the small intestines of various types of DNA repair-deficient mice
| Project/Area Number |
20012037
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
TSUZUKI Teruhisa Kyushu University, 大学院・医学研究院, 教授 (40155429)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATSU Yoshimichi 九州大学, 大学院・医学研究院, 准教授 (00207820)
OHNO Mizuki 九州大学, 大学院・医学研究院, 助教 (70380524)
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| Co-Investigator(Renkei-kenkyūsha) |
YAO Takashi 順天堂大学, 医学部, 教授 (20243933)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 遺伝子 / 核酸 / 癌 / ゲノム / 動物 / 活性酸素 / 突然変異 / 消化管 |
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| Research Abstract |
To elucidate the roles of DNA repair genes in the suppression of oxidative DNA damage-induced tumorigenesis, we performed KBrO3-induced tumorigenesis experiments using Ogg1-, Mth1-, Msh2- or Trp53-deficient mice. We observed an enhanced tumor-formation in the small intestines of Msh2- or Trp53-deficient mice, as compared with the wild type and heterozygous mice. These results indicate that in addition to Mutyh, Msh2 and p53 are involved in the suppression of oxidative stress-induced intestinal tumorigenesis in mice. The number of tumors was marginally increased in Ogg1- or Mth1-deficient mice, in comparison to the wild-type mice, suggesting that Ogg1 and Mth1 may play a limited role in the suppression of intestinal tumorigenesis caused by oxidative stress.
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Research Products
(26 results)
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[Journal Article] Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base.2010
Author(s)
T. Nakamura, S. Meshitsuka, S. Kitagawa, N. Abe, J. Yamada, T. Ishino, H. Nakano, T. Tsuzuki, T. Doi, Y. Kobayashi, S. Fujii, M. Sekiguchi vY. Yamagata
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Journal Title
J. Biol. Chem. 285
Pages: 444-452
Peer Reviewed
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[Book] Significance of Error-avoiding Mechanisms for Oxidative DNA Damage in Carcinogenesis, International Proceeding2008
Author(s)
T. Tsuzuki, T. Isoda, J. Piao, K. Yamauchi, A. Egashira, K. Sakamoto, S. Kura, K. Sakumi, Y. Nakabeppu, Y. Nakatsu
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