2009 Fiscal Year Final Research Report

Molecular chaperones functionally linked to translational control

Research Project

Project/Area Number	20059029
Research Category	Grant-in-Aid for Scientific Research on Priority Areas
Allocation Type	Single-year Grants
Review Section	Biological Sciences
Research Institution	Maebashi Institute of Technology
Principal Investigator	MINAMI Yasufumi Maebashi Institute of Technology, 工学部, 教授 (40181953)
Co-Investigator(Kenkyū-buntansha)	ZENNO Shuuhei 前橋工科大学, 工学部, 教授 (90313204) MATSUMOTO Ken 独立行政法人理化学研究所, 分子昆虫学研究室, 専任研究員 (60222311) MINAMI Michiko 国立大学法人東京学芸大学, 教育学部, 教授 (70272432)
Project Period (FY)	2008 – 2009
Keywords	分子シャペロン / 翻訳 / mRNA
Research Abstract	We found that treatment with the Hsp90 inhibitor geldanamycin (GA) leads to a substantial reduction in the number of HeLa cells that contain processing bodies. Stress granules were also affected by this treatment and eIF4E and 4E-T specifically dissociated from these granules. Moreover, treatment with GA weakened the physical interaction of eIF4E with eIF4G. We conclude that the chaperone activity of Hsp90 is likely to be required for the activities of eIF4E that are necessary for its physiological function.

(3 results)