2010 Fiscal Year Final Research Report
Structural characterization of supramolecular nucleic acid structure based on IR vibrational spectroscopy and quantum chemical calculation
| Project/Area Number |
20350012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
SAIGUSA Hiroyuki Yokohama City University, 大学院・生命ナノシステム科学研究科, 教授 (90162180)
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| Co-Investigator(Kenkyū-buntansha) |
TACHIKAWA MASANORI 横浜市立大学, 生命ナノシステム科学研究科, 教授 (00267410)
OHBA MASASHI 横浜薬科大学, 薬学部, 教授 (60115219)
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| Project Period (FY) |
2008 – 2010
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| Keywords | クラスター |
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| Research Abstract |
We have developed laser desorption technique for generating hydrated clusters of the DNA base pairs and those of nucleoside molecules consisting of base and sugar group, and performed structural characterization based on UV and IR spectroscopy combined with quantum mechanical calculation. We have also implemented this method for vaporizing a nucleotide having sugar-phosphate backbone, and identified the formation of a supramolecular structure.
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