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2010 Fiscal Year Final Research Report

The genetic analysis of calcineurin signaling pathway in schizophrenia.

Research Project

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Project/Area Number 20390316
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

YAMADA Kazuo  The Institute of Physical and Chemical Research, 分子精神科学研究チーム, 副チームリーダー (10322695)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Takeo  独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
OHNISHI Tetsuo  独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (80373281)
HATTORI Eiji  独立行政法人理化学研究所, 分子精神科学研究チーム, 客員研究員 (80399443)
Project Period (FY) 2008 – 2010
Keywords脳・神経疾患 / 遺伝子 / シグナル伝達 / ゲノム / マイクロアレイ
Research Abstract

The calcineurin cascade is central to neuronal signal transduction, and genes in this network are intriguing candidate schizophrenia susceptibility genes. In this study, we performed association studies of calcineurin-related candidate genes by using Japanese schizophrenic pedigrees and case-control samples. In addition, we conducted a genome-wide association study (GWAS), which is a potentially powerful tool for identifying the risk variants that underlie the disease. We found several novel candidate genes for the disease, and unveiled the accumulation of association signals from genes of GABAergic pathways in schizophrenia. Furthermore, we extended our study by using postmortem brains of schizophrenic patients and transgenic mice of candidate genes. These findings support the genetic association of altered calcineurin/GABA signaling with schizophrenia pathogenesis.

  • Research Products

    (37 results)

All 2011 2010 2009 2008 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Association study of Nogo-related genes with schizophrenia in a Japanese case-control sample.2011

    • Author(s)
      Jitoku D, Hattori E, Iwayama Y, Yamada K, Toyota T, Kikuchi M, Maekawa M, Nishikawa T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. (in press)

    • Peer Reviewed
  • [Journal Article] Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples.2011

    • Author(s)
      Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H, Miura T, Kato T, Yoshikawa T, Kanba S
    • Journal Title

      Psychiatry Clin Neurosci. (in press)

    • Peer Reviewed
  • [Journal Article] Genome-wide Association Study of Schizophrenia in Japanese Population.2011

    • Author(s)
      Yamada K, Iwayama Y, Hattori E, Iwamoto K, Toyota T, Ohnishi T, Ohba H, Maekawa M, Kato T, Yoshikawa T
    • Journal Title

      PLoS ONE. (in press)

    • Peer Reviewed
  • [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility.2011

    • Author(s)
      Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35(2)

      Pages: 454-458

    • Peer Reviewed
  • [Journal Article] Analysis of strain-dependent prepulse inhibition points to a role for Shmt1 (SHMT1) in mice and in schizophrenia.2010

    • Author(s)
      Maekawa M, Ohnishi T, Hashimoto K, Watanabe A, Iwayama Y, Ohba H, Hattori E, Yamada K, Yoshikawa T
    • Journal Title

      J Neurochem. 115(6)

      Pages: 1374-1385

    • Peer Reviewed
  • [Journal Article] Further evidence for the role of MET in autism susceptibility.2010

    • Author(s)
      Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, Suda S, Kawai M, Sugihara G, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Neurosci Res. 68(2)

      Pages: 137-141

    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis.2010

    • Author(s)
      Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 153B(6)

      Pages: 1221-1227

    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H
    • Journal Title

      Neurosci Res. 67(2)

      Pages: 181-191

    • Peer Reviewed
  • [Journal Article] Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder.2010

    • Author(s)
      Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 153B(2)

      Pages: 484-493

    • Peer Reviewed
  • [Journal Article] Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain.2010

    • Author(s)
      Bundo M, Iwamoto K, Yamada K, Yoshikawa T, Kato T
    • Journal Title

      Psychiatry Clin Neurosci. 64(1)

      Pages: 57-61

    • Peer Reviewed
  • [Journal Article] The chitinase 3-like 1 gene and schizophrenia : evidence from a multi-center case-control study and meta-analysis.2010

    • Author(s)
      Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S, Yoshikawa T, Ohmori T, Iwata N, Ozaki N, Takeda M
    • Journal Title

      Schizophr Res. 116(2-3)

      Pages: 126-132

    • Peer Reviewed
  • [Journal Article] Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations.2010

    • Author(s)
      Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M
    • Journal Title

      PLoS One. Jan 6;5(1)

      Pages: e8596

    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population.2009

    • Author(s)
      Hattori E, Toyota T, Ishitsuka Y, Iwayama Y, Yamada K, Ujike H, Morita Y, Kodama M, Nakata K, Minabe Y, Nakamura K, Iwata Y, Takei N, Mori N, Naitoh H, Yamanouchi Y, Iwata N, Ozaki N, Kato T, Nishikawa T, Kashiwa A, Suzuki M, Shioe K, Shinohara M, Hirano M, Nanko S, Akahane A, Ueno M, Kaneko N, Watanabe Y, Someya T, Hashimoto K, Iyo M, Itokawa M, Arai M, Nankai M, Inada T, Yoshida S, Kunugi H, Nakamura M, Iijima Y, Okazaki Y, Higuchi T, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(8)

      Pages: 1110-1117

    • Peer Reviewed
  • [Journal Article] A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient.2009

    • Author(s)
      Maekawa M, Iwayama Y, Nakamura K, Sato M, Toyota T, Ohnishi T, Yamada K, Miyachi T, Tsujii M, Hattori E, Maekawa N, Osumi N, Mori N, Yoshikawa T
    • Journal Title

      Neurosci Lett. 462(3)

      Pages: 267-2671

    • Peer Reviewed
  • [Journal Article] Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.2009

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Thanseem I, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Kikuchi M, Tohyama M, Yoshikawa T, Mori N
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(7)

      Pages: 967-976

    • Peer Reviewed
  • [Journal Article] Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations.2009

    • Author(s)
      Yamada K, Hattori E, Iwayama Y, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Okazaki Y, Yoshikawa T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(4)

      Pages: 508-514

    • Peer Reviewed
  • [Journal Article] Variable number of tandem repeat polymorphisms of DRD4 : re-evaluation of selection hypothesis and analysis of association with schizophrenia.2009

    • Author(s)
      Hattori E, Nakajima M, Yamada K, Iwayama Y, Toyota T, Saitou N, Yoshikawa T
    • Journal Title

      Eur J Hum Genet. 17(6)

      Pages: 793-801

    • Peer Reviewed
  • [Journal Article] Mitochondrial DNA haplogroup analysis in patients with bipolar disorder.2009

    • Author(s)
      Kazuno AA, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, Mori N, Yamada K, Yoshikawa T, Kato N, Kato T
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 150B(2)

      Pages: 243-247

    • Peer Reviewed
  • [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism.2008

    • Author(s)
      Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya KJ, Sugihara G, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N
    • Journal Title

      Int J Neuropsychopharmacol. 11(8)

      Pages: 1073-1084

    • Peer Reviewed
  • [Journal Article] Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.2008

    • Author(s)
      Shi J, Wittke-Thompson JK, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B(7)

      Pages: 1047-1055

    • Peer Reviewed
  • [Journal Article] Neurotransmission and bipolar disorder : a systematic family-based association study.2008

    • Author(s)
      Shi J, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B(7)

      Pages: 1270-1277

    • Peer Reviewed
  • [Journal Article] Genetic analyses of roundabout (ROBO) axon guidance receptors in autism.2008

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 147B(7)

      Pages: 1019-1027

    • Peer Reviewed
  • [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder.2008

    • Author(s)
      Anitha A, Nakamura K, Yamada K, Iwayama Y, Toyota T, Takei N, Iwata Y, Suzuki K, Sekine Y, Matsuzaki H, Kawai M, Miyoshi K, Katayama T, Matsuzaki S, Baba K, Honda A, Hattori T, Shimizu S, Kumamoto N, Tohyama M, Yoshikawa T, Mori N
    • Journal Title

      Biol Psychiatry. 63(7)

      Pages: 678-685

    • Peer Reviewed
  • [Presentation] Genome wide association study identifies a potassium channel gene as a susceptibility gene for schizophrenia.2010

    • Author(s)
      山田和男, et al.
    • Organizer
      18th World Congress on Psychiatric Genetics
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2010-10-04
  • [Presentation] 統合失調症におけるゲノムワイド関連解析2010

    • Author(s)
      山田和男, 他
    • Organizer
      第18回日本精神行動遺伝医学会
    • Place of Presentation
      仙台、日本
    • Year and Date
      2010-09-18
  • [Presentation] Association Analysis of Adenosine A1 receptor (ADORA1) and Dopamine D1 receptor (DRD1) genes with schizophrenia in the Japanese population.2009

    • Author(s)
      Gotoh L, et al.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2009-10-22
  • [Presentation] Association Analysis of Adenosine A1 receptor (ADORA1) and Dopamine D1 receptor (DRD1) genes with bipolar disorder in the Japanese population.2009

    • Author(s)
      Kawasaki H, et al.
    • Organizer
      59th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2009-10-22
  • [Presentation] Molecular targets for potentially disturbed lipid metabolism in functional psychoses.2009

    • Author(s)
      Yoshikawa T
    • Organizer
      The 1st Asian Workshop on Schizophrenia Research
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2009-02-01
  • [Presentation] A gene distributed by a chromosomal translocation in 4p15.2 was associated with schizophrenia.2008

    • Author(s)
      Haga S, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
  • [Presentation] Testing genetic models and candidate genes for schizophrenia from an evolutionary viewpoint.2008

    • Author(s)
      Doi N, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
  • [Presentation] Mitochondrial DNA hypothesis if schizophrenia : an integration of epidemiological and pathophysiological aspects.2008

    • Author(s)
      Doi N, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
  • [Presentation] Genetic roles of FABP7, 5 and 3 in functional psychoses.2008

    • Author(s)
      Iwayama Y, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
  • [Presentation] Gene and expression analyses reveal elevated expression of syntaxin 1A in high functioning autism.2008

    • Author(s)
      Anitha A, et al.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-12
  • [Presentation] Genetics of Bipolar disorder.2008

    • Author(s)
      Hattori E
    • Organizer
      2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2008-09-11
  • [Presentation] Genetic architecture that defines endphenotypes in mice and its molecular relevance to mental disorders.2008

    • Author(s)
      Yoshikawa T
    • Organizer
      XXVI CINP Congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2008-07-14
  • [Presentation] Toward Genetics Dissection of Psychiatric Illnesses.2008

    • Author(s)
      Yoshikawa T
    • Organizer
      NIMH Lecture Series
    • Place of Presentation
      Bethesda, MD, USA
    • Year and Date
      2008-05-05
  • [Remarks] ホームページ等

    • URL

      http://molpsych.brain.riken.jp/index.html

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Published: 2012-01-26   Modified: 2016-04-21  

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