Molecular patho-epidemiological study on oral superficial carcinoma in East Asia regions

2011 Fiscal Year Final Research Report

• Project/Area Number: 20406029
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Morphological basic dentistry
• Research Institution: Niigata University
• Principal Investigator: CHENG Jun 新潟大学, 医歯学系, 准教授 (40207460)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Satoshi 新潟大学, 医歯学総合病院, 講師 (30397161) ; SAKU Takashi 新潟大学, 医歯学系, 教授 (40145264) ; IDA Hiroko 新潟大学, 医歯学総合病院, 講師 (60293213) ; YAMAZAKI Manabu 新潟大学, 医歯学系, 助教 (10547516)
• Project Period (FY): 2008 – 2011
• Keywords: 口腔がん / 表在性癌 / 発症機構 / 病理疫学 / 分子病理学

Research Abstract

Oral cancers, especially superficial carcinomas, are increasing in number not only in Japan but also Asian countries, which seems to be in parallel to changing of those countries into aging societies. Epidemiologically and molecular pathologically comparing Japanese cases and East Asian cases, we have shown that oral superficial carcinoma is a lesional complex of borderline malignancies including from epithelial dysplasia to micro-invasive carcinoma by establishing pathological diagnostic criteria for carcinoma in-situ, which were biological evidence-based.

Research Products

• [Journal Article] Keratin-10-positive orthokeratotic dysplasia : a new leukoplakia-type precancerous entity of the oral mucosa (2012)
  • Author(s): Kobayashi T, Maruyama S, Abe T, Cheng J, Takagi R, Saku T.
  • Journal Title: Histopathology Volume: (in press)
  • DOI: DOI:10.1111/j.1365-2559.2012.04283.x
  • Peer Reviewed
• [Journal Article] Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma (2012)
  • Author(s): Metwaly H, Maruyama S, Yamazaki M, Tsuneki M, Abe T, Jen KY, Cheng J, Saku T.
  • Journal Title: Human Pathology
  • DOI: DOI:10.1016/j.humpath.2012.02.006
  • Peer Reviewed
• [Journal Article] Intraepithelially entrapped blood vessels in oral carcinoma in-situ (2012)
  • Author(s): Funayama A, Maruyama S, Yamazaki M, Al-Eryani K, Shingaki S, Saito C, Cheng J, Saku T.
  • Journal Title: Virchows Archive Volume: 460(5) Pages: 473-480
  • DOI: DOI:10.1007/s00428-012-1224-0
  • Peer Reviewed
• [Journal Article] Loss of keratin 13 in oral carcinoma in situ : a comparative study of protein and gene expression levelsusing paraffin section (2012)
  • Author(s): Ida-Yonemochi H, Maruyam S, Kobayashi T, Yamazaki M, Cheng J, Saku T.
  • Journal Title: Modern Pathology
  • DOI: DOI:10.1038/modpathol.2011.218
  • Peer Reviewed
• [Journal Article] Short telomeres in an oral precancerous lesion : Q-FISH analysis of leukoplakia (2012)
  • Author(s): Aida J, Kobayashi T, Saku T, Yamaguchi M, Shimomura N, Nakamura KI, Ishikawa N, Maruyama S, Cheng J, Poon SS, Sawabe M, aida T, Takubo K.
  • Journal Title: Journal of Oral Pathology & Medicine Volume: 41(5) Pages: 372-378
  • DOI: DOI:10.1111/j.1600-0714.2011.01120.x
  • Peer Reviewed
• [Journal Article] Clinicopathological distinction of two categories of oral squamous cell carcinoma of the tongue (2012)
  • Author(s): Saito M, Kobayashi T, Takagi R, Saku T.
  • Journal Title: Oral Medicine & Pathology Volume: 16(2) Pages: 81-88
  • DOI: DOI:10.3353/omp.16.81
  • Peer Reviewed
• [Journal Article] Nuclear translocation ofβ-catenin synchronized with loss of E-cadherin in oral epithelial dysplasia with a characteristic two-phase appearance (2011)
  • Author(s): Alvarado CG, Maruyama S, Cheng J, Ida-Yonemochi H, Kobayashi T, Yamazaki M, Takagi R, Saku T.
  • Journal Title: Histopathology Volume: 59(2) Pages: 283-291
  • DOI: DOI:10.1111/j.1365-2559.2011.03929.x
  • Peer Reviewed
• [Journal Article] Enhancd expression of podoplanin in oral carcinoma in situ and squamous cell carcinomas (2011)
  • Author(s): Funayama A, Cheng J, Maruyama S, Yamazaki M, Kobayashi T, Syafriadi M, Kundu S, Shingaki S, Saito C, Saku T.
  • Journal Title: Pathobiology Volume: 78(3) Pages: 171-180
  • DOI: DOI:10.1159/000324926
  • Peer Reviewed
• [Journal Article] Emergence of keratin 17 vs. loss of keratin 13 : Their reciprocal immunohistochemical profiles in oral carcinoma in situ (2011)
  • Author(s): Mikami T, Cheng J, Maruyama S, Kobayashi T, Funayama A, Yamazaki M, Adeola HA, Wu L, Shingaki S, Saito C, Saku T.
  • Journal Title: Oral Oncology Volume: 47(6) Pages: 497-503
  • DOI: DOI:10.1016/j.oraloncology.2011.03.015
  • Peer Reviewed
• [Journal Article] Differential expression of perlecan receptors,α-dystroglycan and integrinβ1, before and after invasion of oral squamous cell carcinoma (2011)
  • Author(s): Ahsan MS, Yamazaki M, Maruyama S, Kobayashi T, Ida-Yonemochi H, Hasegawa M, Adeola HA, Cheng J, Saku T.
  • Journal Title: Journal of Oral Volume: 40(7) Pages: 552-559
  • DOI: DOI:10.1111/J.1600-0714.2010.00990.x
  • Peer Reviewed
• [Journal Article] Oral cancer in Myanmar : a preliminary survery based on hospital-based cancer registries (2011)
  • Author(s): Oo HN, Myint YY, Maung CN, Oo PS, Cheng J, Maruyama S, Yamazaki M, Yagi M, Sawair FA, Saku T.
  • Journal Title: Journal of Oral Pathology & Medicine Volume: 40(1) Pages: 20-26
  • DOI: DOI:10.1111/j.1600-0714.2010.00938.x
  • Peer Reviewed
• [Journal Article] Acetic acid treatment for wrinkle-free oral mucosal epithelia in paraffin section preparation (2011)
  • Author(s): Ahsan MS, Maruyama S, Cheng J, Al-Eryani K, Yamazaki M, Hasegawa M, Tsuneki M, Saku T.
  • Journal Title: Microscopy Research and Technique Volume: 74(3) Pages: 264-268
  • DOI: DOI:10.1002/jemt.20900
  • Peer Reviewed
• [Journal Article] A computer-aided distinction method of borderline grades of oral cancer (2010)
  • Author(s): Sami MM, Saito M, Muramatsu S, Mikami T, Saku T.
  • Journal Title: IEICE Volume: E93-A(8) Pages: 1544-1552
  • DOI: DOI:10.1587/transfun.E93.A.1544
  • Peer Reviewed
• [Journal Article] Histopathological varieties of oral carcinoma in situ : Diagnosis aided by the immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia (2010)
  • Author(s): Kobayashi T, Maruyama S, Cheng J, Ida-Yonemochi H, Yagi M, Takagi R, Saku T.
  • Journal Title: Pathology International Volume: 60(3) Pages: 156-166
  • DOI: DOI:10.1111/j.1440-1827.2009.02499.x
  • Peer Reviewed
• [Journal Article] Twin-pair rete ridge analysis : a computer-aided method for facilitating objective histopathological distinction between epithelial dysplasia and carcinoma in-situ of the oral mucosa (2010)
  • Author(s): Sami MM, Saito M, Muramatsu S, Mikami T, Al-Eryani K, Sawair FA, Eid RA, Cheng J, Kikuchi H, Saku T.
  • Journal Title: Oral Medicine & Pathology Volume: 14(3) Pages: 89-97
  • DOI: DOI:10.3355/omp.14.89
  • Peer Reviewed
• [Journal Article] Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma : a differential DNA chip analysis between metastatic and nonmetastatic cell systems (2010)
  • Author(s): Maruyama S, Cheng J, Yamazaki M, Zhou XJ, Zhang ZY, He RG, Saku T.
  • Journal Title: Cancer Genetics and Cytogenetics Volume: 196(1) Pages: 14-22
  • DOI: DOI:10.1016/j.cancergencyto.2009.08.02
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ : an aid for histopathologic recognition of their cell proliferation centers (2009)
  • Author(s): Tilakaratne WM, Kobayashi T, Ida-Yonemochi H, Swelam W, Yamazaki M, Mikami T, Alvarado CG, Ahsan MS, Maruyama S, Cheng J, Saku T.
  • Journal Title: Journal of Oral Pathology & Medicine Volume: 38(4) Pages: 348-355
  • DOI: DOI:10.1111/j.1600-0714.2009.00750.x
  • Peer Reviewed
• [Presentation] 口腔粘膜上皮内癌と浸潤癌で対比的なパールカン結合増殖因子の発現様式 (2011)
  • Author(s): 長谷川真弓,程君,丸山智,山崎学,齊藤力,朔敬
  • Organizer: 第56回日本口腔外科学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 20111021-23
• [Presentation] MFG-E8は口腔扁平上皮癌においてアポトーシス細胞処理と腫瘍進展を促進する (2011)
  • Author(s): 山崎学,丸山智,程君,朔敬
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 20111003-05
• [Presentation] Podoplanin regulates the proliferation of oral squamous cell carcinoma cells via its binding to extracellular matrix (2011)
  • Author(s): Tsuneki M, Maruyama S, Yamazaki M, Cheng J, Saku T.
  • Organizer: The 2011 European Multidisciplinary Cancer Congress
  • Place of Presentation: Stockholm
  • Year and Date: 20110923-27
• [Presentation] Hemophagocytosis-induced PAR-2 expression regulates cytoskeletal rearrangement and cell growth of oral squamous cell carcinoma (2011)
  • Author(s): Al-Eryani K, Maruyama S, Yamazaki M, Tsuneki M, Cheng J, Saku T.
  • Organizer: 第22回日本臨床口腔病理学会総会学術大会・第5回アジア口腔病理学会
  • Place of Presentation: 福岡市
  • Year and Date: 20110823-25
• [Presentation] 口腔扁平上皮癌の浸潤性評価:パールカン免疫陽性間質の立体構築 (2011)
  • Author(s): 丸山智,島津徳人,工藤朝雄,青葉孝昭,朔敬
  • Organizer: 第100回日本口腔病理学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20110428-30
• [Presentation] 口腔扁平上皮癌におけるポドプラニン発現の意義 (2011)
  • Author(s): 常木雅之,丸山智,山崎学,程君,朔敬
  • Organizer: 第100回日本口腔病理学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20110428-30
• [Presentation] Perlecan-binding growth factors in oral superficial carcinoma (2010)
  • Author(s): Hasegawa M, Cheng J, Maruyama S, Yamazaki M, Saku T.
  • Organizer: 15^<th> Biennial Congress of the International Association of Oral Pathologists
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 20100816-20
• [Presentation] Acetic acid treatment for wrinkle free oral mucosal epithelia in paraffin section preparation (2010)
  • Author(s): Ahsan MS, Maruyama S, Cheng J, Al-Eryani K, Yamazaki M, Hasegawa M, Tsuneki M, Saku T.
  • Organizer: 第20回日本口腔粘膜病学会・第21回日本臨床口腔病理学会
  • Place of Presentation: 枚方市
  • Year and Date: 20100730-0801
• [Presentation] 口腔粘膜上皮内癌の病理診断の実践的方法とトランスレーショナル研究視点 (2010)
  • Author(s): 朔敬
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京都
  • Year and Date: 20100427-30
• [Presentation] 正角化型口腔異型上皮における構成細胞のテロメア長と染色体不安定性について:Q-FISH法による解析 (2010)
  • Author(s): 相田順子,小林孝憲,丸山智,程君,朔敬,泉山七生貴, 他6名
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京都
  • Year and Date: 20100427-30
• [Presentation] New tissue architecture of oral carcinoma in-situ characterized by intraepithelial stroma and intraepithelial blood vessels : Biological evidence for its histopathological diagnosis (2009)
  • Author(s): Saku T.
  • Organizer: 4^<th> Meeting of Asian Society of Oral and Maxillofacial Pathology
  • Place of Presentation: Beijing, China
  • Year and Date: 20091106-07
• [Presentation] Hemophagocytosis-related keratinization in squamous cell carcinoma and carcinoma in-situ of the oral mucosa (2009)
  • Author(s): Al-Eryani K, Cheng J, Maruyama S, Yamazaki M, Kobayashi T, Saku T.
  • Organizer: Joint ECCO 15-34^<th> ESMO Multidisciplinary Congress
  • Place of Presentation: Berlin, Germany
  • Year and Date: 20090920-24
• [Presentation] Loss ofβ-catenin and E-cadherin in oral epithelial dysplasia with two-phase appearance (2009)
  • Author(s): Alvarado CG, Cheng J, Ida-Yonemochi H, Maruyama S, Ahsan MS, Takagi R, Saku T.
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都市
  • Year and Date: 20090501-03
• [Presentation] 口腔粘膜二層性異型上皮における細胞増殖因子の発現 (2009)
  • Author(s): 長谷川真弓,丸山智,程君,齊藤力,朔敬
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都市
  • Year and Date: 20090501-03
• [Presentation] Recurrence of leukoplakias as evidencefor malignancy : histopathological varieties oforal carcinoma in-situ (2008)
  • Author(s): Saku T.
  • Organizer: Asia-pacific congress onOral Cavity Cancer, 12th annual Meeting ofTaiwan Cooperative Oncology Group
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20081206-07
• [Presentation] 正角化型異型上皮:新しい診断概念の確立とその意義 (2008)
  • Author(s): 小林孝憲,依田浩子,丸山智,程君,高木律男,齊藤力,朔敬
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 東京都
  • Year and Date: 20080820-22
• [Presentation] CK17と14-3-3σの共発現が口腔扁平上皮癌で強調される (2008)
  • Author(s): 三上俊彦,程君,丸山智,小林孝憲,依田浩子,新垣晋,朔敬
  • Organizer: 第19回日本臨床口腔病理学会
  • Place of Presentation: 東京都
  • Year and Date: 20080820-22
• [Presentation] Histopathological diagnosis for oralcancer and precancer (2008)
  • Author(s): Saku T.
  • Organizer: Asian Association of Oraland Maxillofacial Surgeons Lectures andWorkshop
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 20080628-29
• [Presentation] Pathologenesis of round-shaped dyskeratosis in oral carcinoma in-sitiu (2008)
  • Author(s): Al-Eryani K, Maruyama S, Cheng J, Saku T.
  • Organizer: 14^<th> Congress of the International Association of Oral Pathologists
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20080621-26
• [Presentation] New histopathological criteria for oral borderline malignancies (2008)
  • Author(s): Saku T.
  • Organizer: First Clinical Pathology Conference or the Chinese and Asian Academy of Oral Pathologists
  • Place of Presentation: Hangzhou, China
  • Year and Date: 20080518-20
• [Presentation] 口腔粘膜上皮内癌におけるp53遺伝子変異の解析.ワークショップ「口腔粘膜上皮内癌:診断の科学的根拠」 (2008)
  • Author(s): 丸山智
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢市
  • Year and Date: 20080515-17
• [Presentation] 口腔粘膜扁平上皮癌・上皮内癌の再発に関する臨床病理学的検討 (2008)
  • Author(s): 小林孝憲,依田浩子,丸山智,程君,齊藤力,高木律男,朔敬
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢市
  • Year and Date: 20080515-17
• [Remarks]
  • URL: http://www.dent.niigata-u.ac.jp/patho/publications/index.html