2010 Fiscal Year Final Research Report
Berberine, a candidate drug to control the development of Alzheimer's disease
| Project/Area Number |
20590260
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
MARUYAMA Kei Saitama Medical University, 医学部, 教授 (30211577)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | アルツハイマー病 / アミロイド / 認可薬剤 |
|---|
| Research Abstract |
The substances for the treatment of Alzheimer's disease, which decreased Aβ levels, were screened from clinically approved drugs. We identified KM2309 (code name, because of patent application). It inhibited γ-secretase and up-regulated a major Aβ-degrading enzyme neprilysin. Since it has been reported that KM2309 crosses the BBB and it has neuronal protective effect, KM2309 would be a novel drug candidate with safety for Alzheimer's disease.
|
Research Products
(19 results)
