2010 Fiscal Year Final Research Report
Berberine, a candidate drug to control the development of Alzheimer's disease
| Project/Area Number |
20590260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MARUYAMA Kei Saitama Medical University, 医学部, 教授 (30211577)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルツハイマー病 / アミロイド / 認可薬剤 |
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| Research Abstract |
The substances for the treatment of Alzheimer's disease, which decreased Aβ levels, were screened from clinically approved drugs. We identified KM2309 (code name, because of patent application). It inhibited γ-secretase and up-regulated a major Aβ-degrading enzyme neprilysin. Since it has been reported that KM2309 crosses the BBB and it has neuronal protective effect, KM2309 would be a novel drug candidate with safety for Alzheimer's disease.
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