2010 Fiscal Year Final Research Report
Analysis of regulation of antigen-specific IgE production in BALT
| Project/Area Number |
20591184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Chiba University |
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Principal Investigator |
KAGAMI Shin-ichiro Chiba University, 大学院・医学研究院, 助教 (30375654)
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| Co-Investigator(Kenkyū-buntansha) |
中島 裕史 千葉大学, 大学院・医学研究院, 教授 (00322024)
須藤 明 千葉大学, 大学院・医学研究院, 助教 (50447306)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 肺内胚中心様組織 / IL-21 / TFH細胞様細胞 / BTLA / IgE / IgG4関連疾患 / 喘息 |
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| Research Abstract |
We found that TFH-like cells existed in inducible bronchus-associated lymphoid tissue (iBALT) and expressed high levels of ICOS, PD-1 and BTLA in a murine model of asthma. In addition, we found that TFH-like cells produced a large amount of IL-21 upon TCR stimulation. We also found that patients with IgG4-related lacrimal gland enlargement (LGE) developed asthma-like symptoms. All patients with IgG4-related LGE showed ectopic germinal center-like architecture in lacrimal glands and exhibited elevated serum IgE levels. CD4^+ T cells in patients with IgG4-related LGE exhibited enhanced Th2 cytokine production as compared with those in healthy subjects.
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