2010 Fiscal Year Final Research Report
Diffusion tensor abnormality in Alzheimer disease-Correlation with clinical symptoms and prognosis-
| Project/Area Number |
20591456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
TAOKA Toshiaki Nara Medical University, 医学部, 准教授 (30305734)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hiroyuki 奈良県立医科大学, 医学部, 准教授 (70231462)
KICHIKAWA Kimihiko 奈良県立医科大学, 医学部, 教授 (10161506)
KISHIMOTO toshifumi 奈良県立医科大学, 医学部, 教授 (60201456)
KIUCHI kuniaki 奈良県立医科大学, 医学部, 助教 (20398449)
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| Project Period (FY) |
2008 – 2010
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| Keywords | アルツハイマー病 / 拡散テンソル画像 / 大脳辺縁系 / 拡散能 / 拡散異方性 / 認知症 / 拡散テンソルトラクトグラフィー / 鉤状束 |
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| Research Abstract |
Our purpose for this study is to correlate the clinical symptoms of Alzheimer disease with diffusion tensor parameters of limbic system. We made clinical study for approximately 400 cases between the period from April 2009 to March 2011 including clinical study such as MMSE (mini mental state examination), conventional MR image, volumetric MR image and MR tensor image. The analysis of diffusion tensor image revealed that there is increase of diffusivity and decrease of fractional anisotropy for uncinate fascicles of Alzheimer disease according to disease severity, as well as anterior cingulum and posterior cingulum. These diffusion parameters correlated with clinical symptoms better than volumetric analysis in our study. Selection of the threshold value proved to have influence for the diffusion parameters in our study. However, as far as using constant threshold value, the diffusion parameter proved to maintain correlation to the clinical symptoms. We also find out that optimal threshold for analysis is fractional anisotropy of 0.15-0.2. We also found that there is agreement between the voxel based analysis (TBSS : Tract-Based Spatial Statistics) and the tract based analysis.
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Research Products
(22 results)
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[Journal Article] Magnetic resonance plaque imaging to predict the occurrence of the slow-flow phenomenon in carotid artery stenting procedures2010
Author(s)
M Sakamoto, T Taoka, H Nakagawa, K Takayama, T Wada, K Myouchin, T Akashi, T Miyasaka, A Fukusumi, S Iwasaki, K Kichikawa
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Journal Title
Neuroradiology 52
Pages: 275-283
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[Journal Article] Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease : A diffusion tensor tractography study2009
Author(s)
K Kiuchi, M Morikawa, T Taoka, T Nagashima, T Yamauchi, M Makinodan, K Norimoto, K Hashimoto, J Kosaka, Y Inoue, M Inoue, K Kichikawa, T Kishimoto
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Journal Title
Brain Research 1287
Pages: 184-191
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[Presentation] 連合線維と「鉄」2009
Author(s)
田岡俊昭
Organizer
第9回MR Retroscopy勉強会
Place of Presentation
HOTEL PLUMM/COSMO.Y
Year and Date
2009-10-03
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[Remarks] ホームページ等
