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2010 Fiscal Year Final Research Report

New mechanisms of regulation of longitudinal growth of tubular bone

Research Project

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Project/Area Number 20591782
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokushima

Principal Investigator

TAKATA Shinjiro  The University of Tokushima, 病院, 准教授 (20284292)

Co-Investigator(Kenkyū-buntansha) YASUI Natsuo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00157984)
TAKAHASHI Mitsuhiko  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10372715)
ENISHI TETSUYA  徳島大学, 病院, 医員 (20467806)
Project Period (FY) 2008 – 2010
Keywords骨軟骨代謝学
Research Abstract

Circumferential periosteal division (CPD) of diaphysis of femur of rat aged 8 weeks produces longitudinal overgrowth. Periosteum of diaphysis of the right femur was divided circumferentially (CPD group), and the left femur was control (Control group). Bone histomorphometry analysis revealed that CPD stimulates endochondral ossification of CPD group compared with Control group. Three-dimensional microstructure analysis of trabecular bone by μCT system showed that CPD increased number of trabecular bone compared with Control group. These results suggest that periosteum regulates endochondral ossification of tubular bone.

  • Research Products

    (21 results)

All 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (10 results)

  • [Journal Article] Efficacy, tolerability and safety of risedronate in Japanese patients with Paget's disease of bone.2010

    • Author(s)
      Yoh K, Takata S, Yoshimura N, Hashimoto J
    • Journal Title

      J Bone Miner Metab 28

      Pages: 468-476

    • Peer Reviewed
  • [Journal Article] Relationship between Barthel Index scores and ADL in stroke patients during acute phase of rehabilitation.2010

    • Author(s)
      Nakao S, Takata S, Uemura H, Kashihara M, Osawa T, Komatsu K, Masuda Y, Okahisa T, Nishikawa K, Kondo S, Yamada M, Takahara R, Ogata Y, Nakamura Y, Yasui N
    • Journal Title

      J Med Invest 57(1,2)

      Pages: 81-88

    • Peer Reviewed
  • [Journal Article] Early ambulation after total knee arthroplasty prevents patients with osteoarthritis and rheumatoid arthritis from developing deep venous thrombosis.2010

    • Author(s)
      Nakao S, Takata S, Uemura H, Nakano S, Egawa H, Kawasaki Y, Yasui N
    • Journal Title

      J Med Invest 57(1,2)

      Pages: 146-151

    • Peer Reviewed
  • [Journal Article] Nonunion of capital femoral physeal fracture with a large metaphyseal fragment.2010

    • Author(s)
      Yukata K, Kubo T, Matsui Y, Koizumi T, Takata S, Yasui N
    • Journal Title

      J Orthop Trauma 24(8)

      Pages: e75-77

    • Peer Reviewed
  • [Journal Article] Optimal increase in bone mass by continuous local infusion of alendronate during distraction osteogenesis in rabbits.2009

    • Author(s)
      Abbaspour A, Takahashi M, Sairyo K, Takata S, Yukata K, Inui A, Yasui N
    • Journal Title

      Bone 44(5)

      Pages: 917-923

    • Peer Reviewed
  • [Journal Article] The effect of rheumatoid arthritis on the anatomy of the female cervical spine : a radiographical study.2009

    • Author(s)
      Higashino K, Sairyo K, Katoh S, Nakano S, nishi T, yasui N
    • Journal Title

      J Bone Joint Surg 91(8)

      Pages: 1058-1063

    • Peer Reviewed
  • [Journal Article] Percutaneous opening wedge varus osteotomy with a multidrilling guide in Perthes' disease : a technical note on two cases.2009

    • Author(s)
      Kawasaki Y, Hanaoka N, Takahashi M, Egawa H, Yasui N
    • Journal Title

      J Pediatr Orthop B 18(5)

      Pages: 242-247

    • Peer Reviewed
  • [Journal Article] Intramedullary schwanomma with calcification of the epiconus.2009

    • Author(s)
      Hayashi F, Sakai T, Sairyo K, Hirohashi N, Higashino K, Katoh S, Yasui N
    • Journal Title

      Spine J 9(5)

      Pages: e19-23

    • Peer Reviewed
  • [Journal Article] Continuous infusion of insulin-like growth factor-I (IGF-I) into the epiphysis promotes longitudinal bone growth of the tibiae in young rabbits.2008

    • Author(s)
      Abbaspour A, Takata S, Matsui Y, Katoh S, Takahashi M, Yasui N
    • Journal Title

      Int Orthop 32(3)

      Pages: 395-402

    • Peer Reviewed
  • [Journal Article] Continuous local infusion of fibroblast growth factor-2 enhances consolidation of the bone segment lengthened by distraction osteogenesis in rabbit experiment.2008

    • Author(s)
      Abbaspour A, Takata S, Sairyo K, Kato S, Yukata K, Yasui N
    • Journal Title

      Bone 42(1)

      Pages: 98-106

    • Peer Reviewed
  • [Journal Article] Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning of skull.2008

    • Author(s)
      Takata S, Takao S, Yoshida S, Yasui N
    • Journal Title

      J Med Invest 55(3,4)

      Pages: 297-302

    • Peer Reviewed
  • [Presentation] Circumferential periosteal stripping of femoral diaphysis of developing rat produces longitudinal overgrowth and cortical hypertrophy.2010

    • Author(s)
      高田信二郎, 他
    • Organizer
      32^<nd> Annual Meeting for American Society of Bone Mineral Research.
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      20101010-20101015
  • [Presentation] ラット大腿骨骨幹部の全周性骨膜切除は内軟骨性骨化と膜性骨化とを促進する2010

    • Author(s)
      高田信二郎, 他
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京都
    • Year and Date
      20100721-20100723
  • [Presentation] シンポジウムリハビリテ-ション医学領域の基礎研究と臨床応用.骨関節領域の基礎研究2010

    • Author(s)
      高田信二郎
    • Organizer
      第47回日本リハビリテーション医学会学術集会
    • Place of Presentation
      鹿児島市
    • Year and Date
      20100520-20100522
  • [Presentation] 成長期ラット大腿骨骨幹部の全周性骨膜切除が内軟骨性骨化と膜性骨化に及ぼす影響2010

    • Author(s)
      高田信二郎, 他
    • Organizer
      第30回日本骨形態計測学会
    • Place of Presentation
      米子市
    • Year and Date
      20100514-20100515
  • [Presentation] Unilateral circumferential periosteal removal causes overgrowth of rat femur by activation of endochondral ossification of growth plate.2009

    • Author(s)
      高田信二郎, 他
    • Organizer
      31^<st> Annual Meeting of American Society for Bone Mineral Research.
    • Place of Presentation
      Denver, Colorado, USA.
    • Year and Date
      20091111-20091115
  • [Presentation] ラット大腿骨骨幹部の骨膜切除は成長軟骨板における内軟骨性骨化を活性化して骨を延長する2009

    • Author(s)
      高田信二郎, 他
    • Organizer
      第24回日本整形外科学会基礎学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      20091105-20091106
  • [Presentation] ラット大腿骨骨幹部骨膜の全周性切除が長径成長と骨微細構造におよぼす影響2009

    • Author(s)
      高田信二郎, 江西哲也, 他
    • Organizer
      第11回日本骨粗鬆症学会
    • Place of Presentation
      名古屋市
    • Year and Date
      20091014-20091016
  • [Presentation] ラット大腿骨骨幹部の骨膜切除がその長径成長におよぼす影響2009

    • Author(s)
      高田信二郎, 他
    • Organizer
      第46回日本リハビリテーション医学会学術集会
    • Place of Presentation
      静岡市
    • Year and Date
      20090604-20090606
  • [Presentation] 長管骨骨幹部の骨膜切除による長径成長促進と骨形態変化の機序解明2009

    • Author(s)
      高田信二郎, 他
    • Organizer
      第29回日本骨形態計測学会
    • Place of Presentation
      大阪市
    • Year and Date
      20090528-20090530
  • [Presentation] Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning.2008

    • Author(s)
      高田信二郎, 他
    • Organizer
      30^<th> Annual Meeting of American Society for Bone Mineral Research. Montrea, Quebec, Canada
    • Place of Presentation
      Canada.
    • Year and Date
      20080912-20080916

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Published: 2012-01-26   Modified: 2016-04-21  

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