2010 Fiscal Year Final Research Report
Regulation of immune responses by IL-15
Project/Area Number |
20591783
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kyushu University |
Principal Investigator |
HISAKATA Yamada Kyushu University, 生体防御医学研究所, 准教授 (20363369)
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Project Period (FY) |
2008 – 2010
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Keywords | リウマチ病学 |
Research Abstract |
In order to elucidate the pathogenesis of inflammatory diseases such as rheumatoid arthritis (RA), it is important to understand the mechanism of regulating T cell functions that play central role in immune responses. In the present study, we addressed the role of IL-15, one of the proinflammatory cytokines that are upregulated in RA, in T cell functions in vivo by using mouse models. We found IL-15 is especially important in the development, maintenance, and activation of self-specific T cells.
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[Journal Article] Direct recognition of mycobacterial cord factor, trehalose dimycolate, by C-type lectin Mincle.2009
Author(s)
Ishikawa E, Ishikawa T, Morita Y, Toyonaga K, Yamada H, Takeuchi O, Akira S, Kinoshita T, Yoshikai Y. Yamasaki S.
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Journal Title
J Exp Med. 206(13)
Pages: 2879-2888
Peer Reviewed
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[Journal Article] Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.2009
Author(s)
Oyamada A, Ikebe H, Itsumi M, Saiwai H, Okada S, Shimoda K, Iwakura Y, Nakayama K, Iwamoto Y, Yoshikai Y, Yamada H.
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Journal Title
J Immunol. 183(11)
Pages: 7539-7546
Peer Reviewed
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[Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.2008
Author(s)
Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y.
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Journal Title
Immunity. 29(3)
Pages: 438-450
Peer Reviewed
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[Remarks] ホームページ等