2010 Fiscal Year Final Research Report
Establishment of a novel therapeutic approach for neuroblastoma using replication-compitent HSV-1 virus vector
| Project/Area Number |
20592085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Chiba University |
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Principal Investigator |
HISHIKI Tomoro Chiba University, 大学院・医学研究院, 講師 (00375776)
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| Co-Investigator(Kenkyū-buntansha) |
TODO Tomoki 東京大学, 医学部附属病院, 特任教授 (80272566)
YOSHIDA Hideo 千葉大学, 大学院・医学研究院, 教授 (00216194)
SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Takeshi 千葉大学, 医学部附属病院, 講師 (20406044)
TERUI Keita 千葉大学, 医学部附属病院, 助教 (70375773)
YAHATA Eriko 千葉大学, 医学部附属病院, 医員 (40456067)
SATO Yoshiharu 千葉大学, 医学部附属病院, 助教 (60375772)
MITSUNAGA Tetsuya 千葉大学, 医学部附属病院, 助教 (80375774)
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| Co-Investigator(Renkei-kenkyūsha) |
INO Yasushi 東京大学, 医学部附属病院, 特任准教授 ウイルスベクター開発・指導 (50372371)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 神経芽腫 / 腫瘍融解ウイルス / ヘルペスウイルス |
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| Research Abstract |
The antitumor effect of genetically modified human herpes simplex virus-1 (T-01) was assessed in human neuroblastoma models in vitro and in vivo. The results showed that T-01 propagates within and potentially kills neuroblastoma cells with a multiplicity of infection of 0.01. 1x10^6 pfu was capable to show significant growth suppression in nude mice neuroblastoma xenografts. However, T-01 was antagonistic against the cytotoxic effect of cisplatin. Thus, co-use of T-01 and anticancer drugs may not be optimal for the therapeutic strategy for neuroblastomas. T-01 may most be effective when targeted for minimum residual diseases.
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[Journal Article] Src kinase family inhibitor PP2 induces aggregation and detachment of neuroblastoma cells and inhibits cell growth in a PI3 kinase/Akt pathway-independent manner.2011
Author(s)
Hishiki T, Saito T, Sato Y, Mitsunaga T, Terui E, Matsuura G, Saito E, Shibata R, Mise N, Yokoyama Y, Yoshida H.
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Journal Title
Pediatr Surg Int. 27
Pages: 225-230
Peer Reviewed
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[Journal Article] Reevaluation of trkA expression as a biological marker of neuroblastoma by high sensitivity expression analysis-a study of 106 primary neuroblastomas treated in a single institute.2010
Author(s)
Hishiki T, Saito T, Terui K, Sato Y, Takenouchi A, Yahata E, Ono S, Nakagawara A, Kamijo T, Nakamura Y, Matsunaga T, Yoshida H.
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Journal Title
J Pediatr Surg. 45
Pages: 2293-2298
Peer Reviewed
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[Presentation] Re-evaluation of trkA expression as a biological marker of neuroblastoma by high sensitivity expression analysis ～ a study of 106 primary neuroblastomas treated in a single institute～.2010
Author(s)
Hishiki, T, Saito, T, Terui, K, Sato, Y, Takenouchi, A, Yahata, E, Ono, S, Nakagawara, A, Kamijo, T, Nakamura, Y, Matsunaga, T, Yoshida, H.
Organizer
43^<rd> Annual Meeting of the Pacific Association of Pediatric Surgeons.
Place of Presentation
神戸
Year and Date
2010-05-26
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[Presentation] 神経芽腫の予後因子としてのTrkA発現高感度解析による再評価2009
Author(s)
菱木知郎, 齋藤武, 照井慶太, 佐藤嘉治, 武之内史子, 八幡江里子, 大野幸恵, 鎌田稔子, 松永正訓, 吉田英生
Organizer
第25回日本小児がん学会(小児がん46増277,2009)
Place of Presentation
浦安
Year and Date
2009-11-27
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