2010 Fiscal Year Final Research Report
Pain sensations of oral region in rat models of Parkinson's disease
| Project/Area Number |
20592371
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
NIWA Hitoshi Osaka University, 大学院・歯学研究科, 教授 (30218250)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGIMURA Mitsutaka 大阪大学, 大学院・歯学研究科, 准教授 (90244954)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | パーキンソン病 / 痛覚 / 三叉神経 / 疼痛関連行動 / c-Fos / ホルマリンテスト |
|---|
| Research Abstract |
Parkinson's disease model rats (PD rat) were injected formalin into the left upper lip. The numbers of pain-related-behavior (PRB) and c-Fos or ERK positive cells in the trigeminal nucleus caudalis were counted after formalin injection. PD rats with contralateral injection showed a decrease in PRB during the first 5 min, however, there was no significant change in ERK expression compared with sham rats. The number of PRBs and c-Fos expression increase in PD rats with ipsilateral injection. These results suggest that the PD rat is in hyperalgesia, however, the behavioral response to pain is blunted.
|
Research Products
(2 results)
