2010 Fiscal Year Final Research Report
Pain sensations of oral region in rat models of Parkinson's disease
| Project/Area Number |
20592371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NIWA Hitoshi Osaka University, 大学院・歯学研究科, 教授 (30218250)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMURA Mitsutaka 大阪大学, 大学院・歯学研究科, 准教授 (90244954)
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| Project Period (FY) |
2008 – 2010
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| Keywords | パーキンソン病 / 痛覚 / 三叉神経 / 疼痛関連行動 / c-Fos / ホルマリンテスト |
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| Research Abstract |
Parkinson's disease model rats (PD rat) were injected formalin into the left upper lip. The numbers of pain-related-behavior (PRB) and c-Fos or ERK positive cells in the trigeminal nucleus caudalis were counted after formalin injection. PD rats with contralateral injection showed a decrease in PRB during the first 5 min, however, there was no significant change in ERK expression compared with sham rats. The number of PRBs and c-Fos expression increase in PD rats with ipsilateral injection. These results suggest that the PD rat is in hyperalgesia, however, the behavioral response to pain is blunted.
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