2011 Fiscal Year Final Research Report
Functional change in descending pain modulatory system induced by chronic stresses
| Project/Area Number |
20602005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IMBE Hiroki 和歌山県立医科大学, 医学部, 講師 (60326353)
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| Co-Investigator(Kenkyū-buntansha) |
SENBA Emiko 和歌山県立医科大学, 医学部, 教授 (00135691)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Akihisa 和歌山県立医科大学, 医学部, 准教授 (20225022)
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| Project Period (FY) |
2008 – 2011
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| Keywords | ストレス / 疼痛学 / 下行性疼痛調節系 |
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| Research Abstract |
Chronic stress is thought to have the effect that enhances pain sensitivity. It has previously been reported that repeated exposure to cold environment, restraint and forced swim for animal produces hyperalgesia(enhancement of nociceptive reaction). However the mechanism underlying chronic stress-induced hyperalgesia remains unknown. There is descending pain modulatory system that controls perception and response to pain in animal and human brains. In the present study we did not observe chronic stress-induced hyperalgesia in the animal with partial lesion of descending pain modulatory system. These results have demonstrated that the input from descending pain modulatory system is involved in chronic stress-induced hyperalgesia.
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