2009 Fiscal Year Final Research Report
Using bone resorption-related gene-modified mice, analysis of periodontitis model and development of drugs
| Project/Area Number |
20791623
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
KOIDE Masanori Matsumoto Dental University, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 歯周病 / 歯周炎モデル / 歯槽骨吸収 / RANKL / OPG |
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| Research Abstract |
We analyzed of alveolar bones of RANKL-transgenic mice (RANKL-Tg), OPG-deficient mice (OPG-KO) and wild type littermates (WT). The alveolar bones were analyzed in wild-type (WT), RANKL-Tg and OPG-KO mice from 8-week-old to 12-week-old. To estimate alveolar bone loss, the distance from the cemento-enamel junction to the alveolar bone crest was measured by micro-CT. ABL was admitted by neither WT mice nor RANKL-Tg mice. As expected, alveolar bone loss in 12-weeks-old OPG-KO mice was about 2-fold higher than the others. These results suggest that deficiency of OPG is more effective than enhancement of RANKL production in bone resorption and alveolar bone loss.
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[Journal Article] Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.2009
Author(s)
Koide M, Kinugawa S, Ninomiya T, Mizoguchi T, Yamashita T, Maeda K, Yasuda H, Kobayashi Y, Nakamura H, Takahashi N, Udagawa N
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Journal Title
J Bone Miner Res 24
Pages: 1469-80
Peer Reviewed
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