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2022 Fiscal Year Final Research Report

Elucidation and applications of metabolism-related mechanisms associated with hormone-dependent female cancer biology based on the study of patient-derived cancer culture and xenograft systems

Research Project

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Project/Area Number 20H03734
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionSaitama Medical University

Principal Investigator

HORIE KUNIKO  埼玉医科大学, 医学部, 教授 (90261982)

Co-Investigator(Kenkyū-buntansha) 井上 聡  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40251251)
Project Period (FY) 2020-04-01 – 2023-03-31
Keywords乳がん / 子宮体がん / エストロゲン
Outline of Final Research Achievements

In the present study, we analyzed preferential metabolism-related mechanisms associated with the pathophysiology of hormone-dependent female cancers including breast and endometrial tumors utilizing original patient-derived cancer culture and xenograft systems established by our research group. We performed integrative studies of gene expression and epigenetic regulations in these cancer models based on high-throughput sequencing and identified candidate diagnostic and therapeutic targets including TRIM family proteins, RNA-binding proteins, and novel long noncoding RNAs identified by this group, whose tumor-promoting actions were further characterized. The preclinical relevance of some candidate cancer targets was shown by in vivo cancer models and by clinicopathological studies of cancer patient cohorts.

Free Research Field

内分泌学

Academic Significance and Societal Importance of the Research Achievements

本邦の中高年女性を中心に、罹患数・死亡数が増え続ける女性がんの乳がんと子宮体がんは、現在の治療法に対して抵抗性が獲得されると難治化して予後不良になり、その対策が希求されている。新しい診断・治療・予防法の確立のためには、より臨床に近いがんモデルを用いて、難治性がんの標的を見つけることが重要である。本研究では、臨床のがん組織から長期に培養できるがんモデルを用いて、がんが進行する時に変化する代謝などに関わる遺伝子の種類と量、またそれらを決める仕組みは何かを詳しく調べ、その中で重要な働きを担うがんの標的分子となりうるシーズを複数見つけることに成功し、それらの臨床への応用が期待される。

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Published: 2024-01-30  

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