Targeted delivery with receptor of cell penetrating peptide as entrance

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 37030:Chemical biology-related
• Research Institution: Niigata University
• Principal Investigator: Okuda Akiko (田所明子) 新潟大学, 医歯学系, 講師 (60454584)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 膜透過ペプチド / Caveolin-1 / ERK / EGFP

Outline of Final Research Achievements

The Pas2r12 can introduce macromolecules such as antibodies into the cytosol. We expected that this Pas2r12 would lead to the development of new molecular-targeted drugs targeting tissue cells. In this study, We found that the cytosolic transduction of cargo protein by Pas2r12 was significantly reduced one of the caveolin-1 overexpressing strains. We also found that ERK was phosphorylated by Pas2r12 and the complex of Pa2r12 and EGFP.

Free Research Field

ケミカルバイオロジー

Academic Significance and Societal Importance of the Research Achievements

悪性リンパ腫を始めとする癌の治療において、分子標的薬の貢献は非常に大きい。特に、受容体特異的な抗体を用いて、細胞内へと抗がん剤を導入することで効果的で副作用の少ない薬剤が期待できる。本研究はまだ基礎段階ではあるが、細胞内へと高分子を導入できるツールとして意義があると考える。