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2023 Fiscal Year Final Research Report

Regulation of retrograde signaling through axonal transport and its role in the onset of Alzheimer's disease

Research Project

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Project/Area Number 20K07742
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 51030:Pathophysiologic neuroscience-related
Research InstitutionKanagawa Institute of Technology (2021-2023)
Juntendo University (2020)

Principal Investigator

Naoya YAMASHITA  神奈川工科大学, 応用バイオ科学部, 准教授 (40508793)

Project Period (FY) 2020-04-01 – 2024-03-31
Keywords軸索輸送 / 逆行性シグナル / トランスサイトーシス / アルツハイマー病
Outline of Final Research Achievements

Alzheimer's disease (AD) is one of the neurodegenerative diseases that we must find a way to cure. Toxic aggregation of amyloid β (Aβ) in neurons is implicated in AD pathology. However, the mechanisms that induce accumulation of Aβ in the brain remain unclear. In this study, we newly identified an axonal transport dependent neuronal signaling that controls Aβ production. Moreover, we found that disruption of this signaling may be related to the onset of AD. Our study therefore provides a basis for predicting and preventing the onset of AD.

Free Research Field

神経生物学、神経病態学

Academic Significance and Societal Importance of the Research Achievements

人類がADを克服するためには、その発症の引き金となりうるAβの蓄積を引き起こす要因を明らかにする必要がある。本研究では、軸索輸送と呼ばれる神経細胞の生存に関わる機構の新たな役割を見出した。さらに、発見した機構の破綻がAβ蓄積を引き起こしてAD発症に関わる可能性を突き止めた。従って、本研究には、神経細胞の発達や機能の制御における基本原理の解明にとどまらず、AD発症に関わる新しい機構の発見につながる可能性がある。ここに、得られた成果の学術的意義と社会的意義が存在する。

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Published: 2025-01-30  

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