2022 Fiscal Year Final Research Report
A molecular epidemiological study of antimicrobial resistance in bacteria isolated in a prefectural area by using a One Health approach
| Project/Area Number |
20K07815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野坂 生郷 熊本大学, 病院, 教授 (90398199)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 薬剤耐性菌 / ワンヘルス / 感染制御 / 地域ネットワーク |
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| Outline of Final Research Achievements |
Antimicrobial resistance (AMR) has become a global health theat. The national action plan on AMR encourages implementation of regional infection control measures based on a network system. The aim of this study is to clarify the molecular epidemiological features of antimicrobial resistant bacteria in the Kumamoto area under the cooperation of Kumamoto Healthcare-associated Infection Prevention and Control Network. First, there was the trend toward an increase in community-acquired MRSA with the dominant clones with the POT1-106 genotype. Second, low isolation rates (<1%) lasted during the period of survey on carbapenem-resistant Enterobacteriaceae (CRE), and a quarter of CRE isolates examined so far harbored carbapenemases. Finally, we found that locally-grown poultry carried ESBL-producing E.coli (dominance of CTX-M type) at varying levels (average, 40%) depend on individual farms. These results would support our one-health approach for regional infection prevention and control.
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| Free Research Field |
内科学、感染制御
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| Academic Significance and Societal Importance of the Research Achievements |
抗微生物薬耐性(antimicrobial resistance :AMR)は依然として公衆衛生上の脅威であり、本邦のAMRアクションプランでは地域での感染対策への取り組みが求められている。本研究は、県下の主要施設が参加する地域の感染ネットワークが独自に構築した微生物サーベーランスシステムを駆使しており、その分析に加え分子疫学解析を試みることで、より詳細な地域における耐性菌動向を明らかにすることができた。さらに家禽におけるESBL産生大腸菌の浸淫状況も明らかとなった。これらの成果は、地域レベルでのワンヘルスアプローチよるAMR対策の具体化に有益な情報をもたらすものと期待できる。
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