Fundamental research on the construction of an acute kidney injury warning system and reversibility indicators of renal function in the area of severe heart failure.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K07819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Yoshihara Fumiki 国立研究開発法人国立循環器病研究センター, 病院, 部長 (70393220)
• Co-Investigator(Kenkyū-buntansha): 福嶌 教偉 国立研究開発法人国立循環器病研究センター, 病院, 客員部長 (30263247) ; 細田 洋司 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員 (40359807)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 急性腎障害

Outline of Final Research Achievements

(1) The usefulness of urinary shedding tubular epithelial cells for the diagnosis of acute kidney injury (AKI) was investigated in mice with vancomycin-induced AKI. As adrenomedullin (AM) has organ-protective effects in AKI models, AM was administered to rats with chronic kidney injury, a risk factor for AKI, to investigate the clinical application of AM.
(2) A clinical study 'Study on the establishment of an acute kidney injury warning system (vancomycin-induced kidney injury)' was initiated. Urine samples are collected over time from vancomycin-treated patients to identify the characteristics of urinary findings and to study their relationship to clinical findings, including renal function, renal prognosis and vancomycin blood levels.

Free Research Field

腎臓病

Academic Significance and Societal Importance of the Research Achievements

日本人の急性腎障害の頻度は251人/100,000人・年と報告されている。急性腎障害の内、その後7日～90日間に渡り腎機能低下が持続する場合を急性腎臓病と称するが、急性腎臓病は生命予後の悪化と関連することが知られている。急性腎障害、急性腎臓病の薬物治療は確立されていないため、本研究は診断ツールや精度の向上および治療方法開発への基盤的知見を深めることに寄与し得る。