Development of film-type depth-dose measurement system for carbon-ion beams and its application to multi-institutional clinical dose intercomparison

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K08013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: National Institutes for Quantum Science and Technology
• Principal Investigator: Kanematsu Nobuyuki 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 物理工学部, 次長 (10221889)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: carbon-ion radiotherapy / high-LET radiation / biological dose / dosimetry

Outline of Final Research Achievements

In ion-beam radiotherapy, the dose of the beam administered into the patient's body is prescribed as a biological dose, which is a numerical representation of the cell-killing effect. That cannot be measured with commercially available dosimeters that simply measure absorbed dose to quantify administered energy. In this study, we designed and produced a prototype biological dosimeter and evaluated its performance through beam experiments. We have published five original papers and one review paper with content related to this research.

Free Research Field

医学物理学

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は複雑な最新の医療技術の普及と安全な利用を共に実現することにある。出版された論文は全て炭素イオン線治療のさらなる発展を促進するものであるが、その障害となり 得るのが臨床現場での炭素イオン線の生物学的効果比の計測技術が未確立であることであるため、これを課題とする本研究の 必要性と重要性がますます高まったと言える。