2022 Fiscal Year Final Research Report
Impact of pretreatment whole-tumor perfusion and diffusion parameters combined with glucose metabolism on local control for non-small cell lung cancer treated with stereotactic body radiotherapy
| Project/Area Number |
20K08098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Hirosaki University |
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Principal Investigator |
Aoki Masahiko 弘前大学, 医学研究科, 教授 (70292141)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 肺癌 / 体幹部定位放射線治療 / dual-energy CT / FDG-PET / DWIBS / 低酸素 / 嫌気性解糖 / 拡散係数 |
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| Outline of Final Research Achievements |
This study aimed to investigate the correlation between the average iodine density and water density detected by dual-energy CT and the maximum standardized uptake value (SUVmax) yielded by FDG-PET scan, and clarify the usefulness as a prognostic indicator for non-small cell lung cancer treated with stereotactic body radiotherapy.
As a result of analysis of 299 lung cancer cases, a weak negative correlation was observed between iodine density and SUVmax, and a medium positive correlation was observed between SUVmax and water density. High SUVmax and low iodine density were significant poor prognostic factors. The overall survival rate and local control rate after stereotactic body radiotherapy were clearly poor in the patient group having both factors.
This study indicated that the group with high SUVmax and low iodine density was identified as the high risk of recurrence of stereotactic body radiotherapy for non-small cell lung cancer.
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| Free Research Field |
放射線科学
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| Academic Significance and Societal Importance of the Research Achievements |
悪性腫瘍のおよそ8割は好気性環境下においても嫌気性解糖を行っていることが知られており、その様な腫瘍は 腫瘍内の酸素分圧に関係なくブドウ糖代謝が亢進している。ブドウ糖代謝は血流低下や栄養不足等の劣悪な環境にあるがんにとってエネルギーを得るための重要な反応であり、がんの増殖にも重要な役割を果たしている。中でも低酸素下で嫌気性解糖を行っている腫瘍はとりわけ放射線抵抗性かつ悪性度が高いと考えられる。多数例による本研究の結果、dual energy CTとFDG-PETを行うことにより、その様な腫瘍を事前に絞り込むことができ、それらに対する線量増加や分割法の工夫により治療成績の更なる向上が期待できる。
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