2022 Fiscal Year Final Research Report
Identifying the specific marker and development of a novel therapy for radiation-induced atherosclerosis
| Project/Area Number |
20K08446
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
南 学 京都大学, 医学研究科, 准教授 (90511907)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 動脈硬化 / 虚血性血管障害 / 放射線照射 / 細胞老化 / 慢性炎症 |
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| Outline of Final Research Achievements |
The aim of this research is to elucidate the mechanism of progression of atherosclerosis after irradiation for the future establishment of prevention method for the radiation-induced vasculopathy. Three points as follows were confirmed by the basic research using the mouse model of radiation-induced carotid atherosclerosis we established. 1)Irradiation promotes atherosclerotic change of the carotid artery. 2)DNA damage persists in the irradiated endothelial cell and smooth muscle cells in the media. 3)Parts of the irradiated endothelial cells and smooth muscle cells are positive for the marker of cellular senescence.
The results of our study clearly showed the possibility of atherosclerosis progression through Senescence-associated secretary phenotype by aging cells with DNA damage.
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| Free Research Field |
動脈硬化 脳血管障害 頚動脈狭窄
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| Academic Significance and Societal Importance of the Research Achievements |
放射線照射が動脈硬化の危険因子であることは知られている。また、癌治療後の生存者の半数近くが何らかの放射線治療を受けているため、放射線治療の副作用としての血管障害は臨床的に重要な問題である。近年、癌に対する集学的治療の進歩により、長期生存者が増加しているため、今後、放射線誘発性の動脈硬化の患者の急増が予想される。さらに、わが国の急速な高齢者人口の増加等の背景を考慮すると、放射線誘発性の動脈硬化促進機序を明らかにし、それに基づく適切な予防および治療法の確立は極めて重要な課題と言える。治療対象は、放射線照射を併用する全ての疾患が適応となり得るため、その臨床的意義も大きい。
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