Aiming to overcome gastrointestinal cancer by controlling cancer microtubule dynamics using innovative therapeutic tools

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Gunma University
• Principal Investigator: Sohda Makoto 群馬大学, 医学部附属病院, 准教授 (70507326)
• Co-Investigator(Kenkyū-buntansha): 横堀 武彦 群馬大学, 未来先端研究機構, 准教授 (60420098) ; 酒井 真 群馬大学, 医学部附属病院, 講師 (70420099) ; 佐伯 浩司 群馬大学, 大学院医学系研究科, 教授 (80325448)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 微小管ダイナミクス / STMN1 / PIP化合物

Outline of Final Research Achievements

As basic research prior to examination of gastrointestinal cancer, examinations of lung cancer and pancreatic cancer were conducted. A cell line obtained by adding the STMN1 PIP compound to each cell line was subcutaneously injected into mice to evaluate the tumor suppressive effect. Based on the results of this basic research, we assumed that STMN1 PIP would similarly inhibit the growth of esophageal and gastric cancers, and conducted similar studies using esophageal and gastric cancer cell lines. If it can be confirmed that STMN1 PIP exhibits tumor growth inhibitory effects, we have been studying with the aim of becoming a new treatment method for taxane drug-resistant cancers. We have tried to reset the timing and dose of drug administration using several cell lines, but we were unable to set the timing and dose sufficiently, so we did not proceed to the planned investigation of esophageal cancer and gastric cancer.

Free Research Field

消化管外科

Academic Significance and Societal Importance of the Research Achievements

研究の目的は革新的治療ツールを利用した癌微小管ダイナミクス制御による消化管癌の克服を目指した検討であり、食道癌および胃癌に対する新規治療薬開発のためにSTMN PIPの治療効果から新たな治療法の開発を期待して検討を行ってきた。予備実験から本実験に進める検討を行ってきたが薬剤容量や投与のタイミング設定ができず予定期間内に結果を提示できなかったが、STMN PIP治療は有用な治療法となり得る可能性が強く示唆されることから今後も検討を進めていく予定であり学術的意義は大きいと考えている。