A novel multilayered arterial graft to induce an ideal vessel remodeling

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K09158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55030:Cardiovascular surgery-related
• Research Institution: Nippon Medical School
• Principal Investigator: Tara Shuhei 日本医科大学, 医学部, 講師 (80465319)
• Co-Investigator(Kenkyū-buntansha): 中澤 靖元 東京農工大学, 工学(系)研究科(研究院), 教授 (20456255)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 生分解性素材 / 人工血管 / 血管リモデリング / 多層性構造

Outline of Final Research Achievements

Silk fibroin (SF) with a long absorption period, and polyvinyl alcohol (PVA) with a short absorption period, were used to fabricate a multi-layered sheet by changing the ejection speed stepwise. The stress-strain curve obtained from the tensile test showed that the higher the PVA ratio, the lower the Young's modulus and the maximum strength. In a cell adhesion test using human dermal microvascular endothelial cells (2 hours after seeding), good cell adhesion was confirmed for both the composition corresponding to the luminal surface of the blood vessel and the outermost layer of the multilayer sheet. Finally, an implantation into the rat abdominal aorta was performed, and good tissue remodeling was confirmed.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、多層構造により血管リモデリングの促進が示された。この結果により、人工血管の素材と構造において、これまでにない新しい方向性が示された。将来的に様々な生体吸収性素材の組み合わせることにより、最適な人工血管素材を創製する足掛かりになることが期待される。