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2023 Fiscal Year Final Research Report

Identification of lifestyle habits related to improving insulin resistance for the development of new preventive methods for kidney stones.

Research Project

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Project/Area Number 20K09544
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionNagoya City University

Principal Investigator

Ando Ryosuke  名古屋市立大学, 医薬学総合研究院(医学), 教授 (30381867)

Co-Investigator(Kenkyū-buntansha) 田口 和己  名古屋市立大学, 医薬学総合研究院(医学), 准教授 (00595184)
鈴木 貞夫  名古屋市立大学, 医薬学総合研究院(医学), 教授 (20226509)
安井 孝周  名古屋市立大学, 医薬学総合研究院(医学), 教授 (40326153)
Project Period (FY) 2020-04-01 – 2024-03-31
Keywords尿路結石 / インスリン抵抗性 / 疫学
Outline of Final Research Achievements

Insulin resistance was a significant risk factor for the development of kidney stones in men. In contrast, there was no association between insulin resistance and the development of kidney stones in women. In men, as insulin resistance increased, the percentages of walking more than 2 hours per day and sitting less than 6 hours per day decreased significantly. In women, on the other hand, no association was found between insulin resistance and physical activity level. The results of this study indicate that gender differences exist in the effect of insulin resistance on the development of kidney stones. The results also suggest that in men, insulin resistance is involved in the development of kidney stones via a decrease in physical activity.

Free Research Field

臨床疫学

Academic Significance and Societal Importance of the Research Achievements

本研究により、日本人男性において尿路結石の発症にインスリン抵抗性が関与していることが明らかになった。さらにインスリン抵抗性に関連する生活習慣として身体活動度について調査したところ、1日当たりの歩行時間が短く、座位時間が長いことがインスリン抵抗性と関連していた。したがって身体活動習慣を改善し、インスリン抵抗性を改善することが尿路結石の発症予防につながることを示す社会的意義の大きい研究成果が得られた。

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Published: 2025-01-30  

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