Efficient tumor delivery using an albumin multimer of a near-infrared fluorescence dye for boron neutron capture therapy

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K16773
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Showa Pharmaceutical University
• Principal Investigator: Onoe Satoru 昭和薬科大学, 薬学部, 助教 (90756107)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: ホウ素中性子捕捉療法 / 光イメージング / アルブミン / ホウ素含有蛍光色素 / EPR効果

Outline of Final Research Achievements

In this study, for development of boron neutron cature therapy (BNCT) agents that can both diagnostic and therapeutic with the same agent, I aimed to develop albumin multimers to be used as carriers and novel boron-containing near-infrared fluorescence dyes with high-binding affinity to albumin.
In the development of albumin multimers, although blood retention increased with multimerization, valence modulation is important for the accumulation of cancer. In the development of novel boron-containing near-infrared fluorescence dyes, the introduction of a negatively charged functional groups increased the binding affinity to albumin and affected cancer accumulation.
The combination of albumin multimer with improved cancer selectivity and the dyes developed in this study could be a useful BNCT agent.

Free Research Field

放射線科学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、申請者らが以前開発したホウ素含有近赤外蛍光色素を基にして、BNCTに欠くことができないホウ素をがんに効率よく送達する技術を開発する上で有用な知見を与えるものである。この技術が開発されれば、新たながん治療として注目されているBNCTに強く貢献できるため、本研究の成果の社会的意義は大きいと考える。