Exploration of new dosimetry methods using a combination of polymer gel dosimetry and biological assessment methods

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K16810
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Nagasaki University
• Principal Investigator: Imamichi Shoji 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (40761599)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 中性子線 / ポリマーゲル線量計

Outline of Final Research Achievements

In this study, we aimed to develop a dosimeter that enables deep dose evaluation by particle therapy and biological evaluation at the same time. In addition, basic data on cell damage evaluation and dose evaluation methods by irradiation of three-dimensional objects were also explored. In the development of a polymer gel dosimeter with a composition that enables cell culture, we developed a polymer gel dosimeter candidate that uses PBS, which shows a dose-dependent color reaction. In addition, a polymer gel dosimeter with the possibility of short-time cell culture was also developed and improved. A method for deep dose evaluation by stacking three mice and the variation of inflammatory response factor HMGB1 by neutron irradiation were clarified.

Free Research Field

放射線生物学

Academic Significance and Societal Importance of the Research Achievements

本研究で開発した深部線量を可視化する新しいポリマーゲル線量計は今後の放射線治療の高精度化に資することが期待される。HMGB1による線量損傷応答反応は新しい放射線応答の指標になりうることが考えられる。また、小動物を積層する新しい評価系は任意深さに腫瘍組織を配置も可能とする新しい深部線量評価手法となりうることと、中型・大型動物の代替となることが期待される。