The Effect of Anesthetic Choice on Prognosis and Immune Function in Pediatric Cancer

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K17836
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kobe University
• Principal Investigator: Ooi Mayu 神戸大学, 医学部附属病院, 助教 (10716567)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 全身麻酔薬 / 小児 / 悪性腫瘍 / 免疫機能 / 長期予後

Outline of Final Research Achievements

We analyzed the effects of general anesthetics on leukemia cell viability, mitochondrial function, and immune function in vitro using the leukemia cell lines HL60 and BALM-9 cells. HL60 and BALM-9 cells showed no cytotoxicity induced by sevoflurane or propofol. Sevoflurane activated mitochondrial respiration and ATP production and increased ROS production in differentiated HL60 cells. Propofol activated mitochondrial respiration and ATP production but did not affect ROS production. These results suggest that propofol may be less likely to produce ROS when mitochondrial respiration is activated.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

全身麻酔薬の選択が小児血液腫瘍患者における予後や免疫機能へ影響する可能性がある。小児では腫瘍の切除術のみならず軽微な処置に対して全身麻酔を行うことが多く、成人よりも全身麻酔薬に暴露する機会が多い。また、麻酔薬と癌の長期転機についての研究は成人を対象としており小児のエビデンスは少ない。そのため小児癌患者に対し麻酔薬の選択が与える影響について調べることは急務である。