2022 Fiscal Year Final Research Report
Systemic antitumor immune response following preoperative tumor embolization for the patients with spinal metastasis
| Project/Area Number |
20K18026
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 56020:Orthopedics-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 転移性脊椎腫瘍 / 脊椎転移 / 腫瘍脊椎骨全摘術 / 凍結治療 / 凍結免疫 / 腫瘍塞栓術 / Abscopal効果 |
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| Outline of Final Research Achievements |
The results of this study revealed that in addition to cryoimmunity from liquid nitrogen-treated bone grafts, tumor necrosis effect from spinal tumor embolization, which is performed before spinal tumor surgery, and cancer immunosenescence effect from necrosis were found. Specifically, the timing of the cancer-specific immunosenescence effect peaked at 1 week to 1 month postoperatively and gradually tapered off. While the tumor necrosis effect of preoperative tumor embolization was found to enhance cancer immunity, the effect was found to be limited. Further validation of the temporal trend of the immune-enhancing effect of preoperative embolization may establish an effective method of adjuvant administration, such as anti-PD1 antibody.
Translated with www.DeepL.com/Translator (free version)
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| Free Research Field |
脊椎外科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、脊椎腫瘍手術における術前腫瘍塞栓術の有効性が、手術時の出血のリスクを抑えること以外に、周術期における癌免疫を増強させる効果の２つの意義があることが明らかとなった。今後癌免疫療法の発展にともない、液体窒素処理骨移植と脊椎腫瘍塞栓術の組み合わせは、脊椎転移の根治的治療として、治療の選択肢として有効な選択肢の一つとして有効であると考えられる。免疫チェックポイント阻害薬等のアジュバント物質を適切な方法で追加投与することでがん免疫賦活化の相乗効果が得られ、局所治療に加え全身の遠隔転移巣の治療へと繋がる戦略が重要であると考えられた。
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