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2022 Fiscal Year Final Research Report

IgA response in relation to the salivary microbiota of diabetic patients with periodontal disease.

Research Project

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Project/Area Number 20K18521
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionOsaka Medical and Pharmaceutical University

Principal Investigator

Omori Michi  大阪医科薬科大学, 医学部, 助教 (60803137)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywords口腔細菌叢 / IgA抗体 / 糖尿病
Outline of Final Research Achievements

The aim of this study was to characterize the oral bacterial environment of diabetic patients with a focus on the salivary microbiota and immunoglobulin A (IgA) antibody response. We found that the salivary microbiota of diabetic and prediabetic subjects was different from that of healthy subjects. In addition, salivary IgA antibody responses differed among bacterial species and were associated with salivary microbiota, and may be related to glycemic status.

Free Research Field

口腔微生物学,口腔免疫学

Academic Significance and Societal Importance of the Research Achievements

口腔細菌叢は,全身状態と関連することが近年明らかになってきている。口腔細菌叢を規定する要因の一つとして宿主の免疫応答性,なかでも口腔の IgA 抗体応答性が関連する可能性を明らかにしたことは,学術的意義がある。また,本研究結果は,糖尿病および前糖尿病の段階を唾液の細菌叢によってスクリーニングできる可能性を示唆している。世界的な高齢化の進行により,今後糖尿病患者の増加が予測されていること,早期の発見が糖尿病予後と関連することから,臨床的意義がある。

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Published: 2024-01-30  

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