2021 Fiscal Year Final Research Report

Elucidation of articular joint homeostasis regulated by the cellular network in the synovium

Research Project

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Project/Area Number	20K20473
Project/Area Number (Other)	19H05565 (2019)
Research Category	Grant-in-Aid for Challenging Research (Pioneering)
Allocation Type	Multi-year Fund (2020) Single-year Grants (2019)
Review Section	Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research Institution	The University of Tokyo
Principal Investigator	Tanaka Sakae 東京大学, 医学部附属病院, 教授 (50282661)
Co-Investigator(Kenkyū-buntansha)	齋藤琢東京大学, 医学部附属病院, 准教授 (30456107) 岡田慶太東京大学, 医学部附属病院, 助教 (50759173) 千々松良太東京大学, 医学部附属病院, 特任助教 (60803210) 森大典東京大学, 医学部附属病院, 届出研究員 (60835354)
Project Period (FY)	2019-06-28 – 2022-03-31
Keywords	滑膜 / 軟骨 / マクロファージ / 線維芽細胞 / シングルセル解析
Outline of Final Research Achievements	The aim of this study is to elucidate the role of synovium in the system of articular joints, especially focusing on the cellular communication. The study was focused on synovium, which has an essential role on the joint homeostasis. We have analyzed various stages of synovial tissues of mouse model using the novel molecular biological technology such as single cell analysis, NGS analysis, and several expression analyses. We generated a mouse osteoarthritis model and a minimized mechanical stress model(MMS model), and analyzed the changes in the synovium and cartilage.
Free Research Field	分子細胞生物学
Academic Significance and Societal Importance of the Research Achievements	本研究成果により関節の恒常性機構の一端を解明することが出来た。関節滑膜における細胞間ネットワークを明らかにすることで滑膜と軟骨、関節の恒常性制御メカニズムを明らかにした。わが国で医療課題となっている変形性関節症における病態解明に繋がる成果であり、飛躍的に同分野における研究が進むことが予想される。