2021 Fiscal Year Final Research Report
Dynamic fluctuation characteristics of cellular force generations and solid mechanical roles during organogenesis
Project/Area Number |
20K20958
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Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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Allocation Type | Multi-year Fund |
Review Section |
Medium-sized Section 18:Mechanics of materials, production engineering, design engineering, and related fields
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Research Institution | Kanazawa University |
Principal Investigator |
Okuda Satoru 金沢大学, ナノ生命科学研究所, 准教授 (80707836)
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Project Period (FY) |
2020-07-30 – 2022-03-31
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Keywords | 生体力学 / シミュレーション |
Outline of Final Research Achievements |
Organogenesis in multicellular organisms is a self-organized deformation process that is robustly controlled at the macroscopic tissue level. On the other hand, organogenesis is also a non-equilibrium process driven by cellular force generation and involves large "fluctuations" at the microscopic molecular and cellular levels. In particular, fluctuations in force generation in the cytoskeleton are involved in the control of mechanical properties at the tissue level and are necessary for proper organogenesis. In this study, we used the collective motion of multicellular organisms as an example to elucidate the effects of fluctuations in force generation of cells on their collective motion.
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Free Research Field |
生体力学
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Academic Significance and Societal Importance of the Research Achievements |
材料力学的な理解を目指す本研究は,これまで未知であった器官形成の適応的な制御機構について,内部構造に基づく新しい理解を与えると期待される.特に,網膜オルガノイドを題材とした本研究は,コロボーマと呼ばれる発生異常など,正常な器官形成の制御機構のみならず,その頑強性の破綻により生じる疾患機構の理解にも寄与すると考えられる.
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