2021 Fiscal Year Final Research Report
Analysis of inflammatory cells in age-related chronic inflammation
| Project/Area Number |
20K21512
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 49:Pathology, infection/immunology, and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
Utano Tomaru 北海道大学, 医学研究院, 准教授 (20360901)
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| Project Period (FY) |
2020-07-30 – 2022-03-31
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| Keywords | 加齢 / 自己ペプチド / 慢性炎症 / 老化モデル |
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| Outline of Final Research Achievements |
Accumulation of age-related abnormal T cells induces chronic inflammation, which is involved in the pathogenesis of various age-related diseases such as lifestyle-related diseases and cancer. In this study, we investigated that the alteration of self-antigens in aging induced chronic inflammation. Using oxidative stress-fragile mice showing age-related phenotypes, we found that altered self-antigens caused by cellular stress induced increased number of CD44highCD122highCD49dhigh CD8+ T cells and chronic inflammation.
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| Free Research Field |
病理学
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢化社会を迎えた我が国にとって、健康寿命の延長につながる萌芽的研究の推進は重要な課題である。T細胞の加齢による変化や免疫老化については、既報研究の研究手法は若齢および老齢マウスの比較検討、リンパ球分化に関わる転写因子の遺伝子改変動物、癌免疫領域の研究が主体であった。本研究により、新規性のある老化形質を示す酸化ストレス脆弱化マウスを用いた研究を推進することで細胞ストレスよる自己抗原の変容が慢性炎症を惹起することが明らかとなった。加齢による慢性炎症のメカニズム解明に向けて新たな知見が得られた。
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