Development of Diagnostic and Therapeutic Support System based on Novel Brain Atlas with Morphological, Functional and Pathological Information

2011 Fiscal Year Final Research Report

• Project/Area Number: 21300185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokyo
• Principal Investigator: MASUTANI Yoshitaka 東京大学, 医学部附属病院, 講師 (20345193)
• Co-Investigator(Renkei-kenkyūsha): HAYASHI Naoto 東京大学, 医学部附属病院, 特任准教授 (10261992) ; SUZUKI Yuichi 東京大学, 医学部附属病院, 放射線技師 (70420221) ; ABE Osamu 日本大学, 医学部付属病院, 教授 (50302716) ; KAMADA Kyousuke 旭川医科大学, 医学部付属病院, 教授 (80372374)
• Project Period (FY): 2009 – 2011
• Keywords: 検査診断システム / 脳アトラス / 治療支援

Research Abstract

In this study, we aimed at construction of an "integrated brain atlas" as a standard brain map consisting of morphological, functional and pathological information of brain, and its application to diagnosis and therapy. We developed various techniques and systems for MR imaging, image processing and display for diagnostic support, surgical navigation. As a result, we achieved an integrate atlas of multivariate map including biological diffusional information, and completed systems for diagnostic and therapeutic aid, and performed preliminary experiments.

Research Products

• [Journal Article] Motion-robust diffusion tensor acquisition at routine 3T magnetic resonance imaging (2010)
  • Author(s): Hasina Yasmin, Hiroyuki Kabasawa, Shigeki Aoki, Osamu Abe, Yoshitaka Masutani, Naoto Hayashi and Kuni Ohtomo
  • Journal Title: Japanese journal of radiology Volume: 28 Pages: 27-33
  • Peer Reviewed
• [Journal Article] CIRCUS : An MDA platform for clinical image analysis in hospitals (2010)
  • Author(s): Yukihiro Nomura, Naoto Hayashi, Yoshitaka Masutani, Takeharu Yoshikawa, Mitsutaka Nemoto, Shohei Hanaoka, Soichiro Miki, Eriko Maeda, Kuni Ohtomo
  • Journal Title: Mass-Data Analysis of Images and Signals Volume: 2(1) Pages: 112-127
  • Peer Reviewed
• [Presentation] Robust DKI Computation Method and its Application for Building Brain Atlas with Multiple Diffusion MRI Parameters (2012)
  • Author(s): Yoshitaka Masutani, Shigeki Aoki
  • Organizer: CARS 2012
  • Place of Presentation: Pisa, Italy
  • Year and Date: 2012-06-28
• [Presentation] General Closed-from Expressions for DKI Parameters and Their Application to Fast and Robust DKI Computation based on Outlier Removal (2012)
  • Author(s): Yoshitaka Masutani, Shigeki Aoki
  • Organizer: ISMRM 20th Scientific Meeting & Exhibition
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2012-05-08
• [Presentation] CIRCUS+:遠隔読影環境のための統合的診断支援およびCAD開発プラットフォーム (2012)
  • Author(s): 増谷佳孝,野村行弘,三木聡一郎,臼井敦,大野孝,原真,松尾義朋,吉川健啓,林直人,大友邦
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-13
• [Presentation] 拡散尖度イメージングにおける様々な計算手法の比較とそのアトラス構築への応用 (2012)
  • Author(s): 増谷佳孝,青木茂樹
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 那覇
  • Year and Date: 2012-01-19
• [Presentation] On closed form expression of diffusion kurtosis for more than 3 b values (2011)
  • Author(s): Yoshitaka Masutani, Shigeki Aoki
  • Organizer: International Joint Symposium-Ultra High Field MRI
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-11-07
• [Presentation] Tract-Specific Analysisのための全自動かつ高速な帯状束の抽出法に関する研究 (2011)
  • Author(s): 伊藤賢司,増谷佳孝,青木茂樹,鈴木雄一,井野賢司,國松聡,大友邦
  • Organizer: 第39回日本核磁気共鳴医学会大会
  • Place of Presentation: 北九州
  • Year and Date: 2011-10-01
• [Presentation] Diffusionalkurtosisimagingを利用した特発性正常圧水頭症の錐体路に関する検討 (2011)
  • Author(s): 福永一星,中西淳,堀正明,増谷佳孝,佐藤秀二,濱崎望,中島円,宮嶋雅一,新井一,青木茂樹,妹尾淳史
  • Organizer: 第39回日本核磁気共鳴医学会大会
  • Place of Presentation: 北九州
  • Year and Date: 2011-09-29
• [Presentation] Diffusional kurtosis imagingを用いた多発性硬化症患者のnormal appearing white matterに対する定量解析 (2011)
  • Author(s): 吉田茉莉子,堀正明,福永一星,横山和正,濱崎望,鎌形康司,下地啓五,中西淳,鈴木由里子,桑鶴良平,笹井啓資,青木茂樹,増谷佳孝
  • Organizer: 第39回日本核磁気共鳴医学会大会
  • Place of Presentation: 北九州
  • Year and Date: 2011-09-29
• [Presentation] 拡散MRイメージングにおける解析的な拡散尖度計算の一手法 (2011)
  • Author(s): 増谷佳孝,青木茂樹
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-12
• [Presentation] A unified framework for concurrent detection of anatomical landmarks for medical image understanding (2011)
  • Author(s): Mitsutaka Nemoto, Yoshitaka Masutani, Shouhei Hanaoka, Yukihiro Nomura, Takeharu Yoshikawa, Naoto Hayashi, Naoki Yoshioka, Kuni Ohtomo
  • Organizer: SPIE Medical Imaging 2011
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-02-12
• [Presentation] 交叉線維部における局所HARDI撮影の追加によるTractographyの描出能向上 (2010)
  • Author(s): 伊藤賢司,増谷佳孝,鈴木雄一,青木茂樹,阿部修,國松聡,大友邦
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば
  • Year and Date: 2010-10-01
• [Presentation] Q-Ball TractographyとfMRIを用いた皮質延髄路描出 (2010)
  • Author(s): 鈴木雄一,増谷佳孝,伊藤賢司,井野賢司,渡辺靖志,佐竹芳朗,後藤政実,飯田恭人,矢野敬一,大友邦
  • Organizer: 第38回日本磁気共鳴医学会大会
  • Place of Presentation: つくば
  • Year and Date: 2010-10-01
• [Presentation] Designing Tract-adaptive MPG Sets for Faster Acquisition of HARDI Data (2010)
  • Author(s): Yoshitaka Masutani, Kenji Itoh, Yuichi Suzuki, Osamu Abe, Shigeki Aoki, Kuni Ohtomo
  • Organizer: Computer Assisted Radiology and Surgery(CARS) 2010
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2010-06-22
• [Presentation] HARDIにおけるMPG削減のための実験的一手法 (2010)
  • Author(s): 増谷佳孝,鈴木雄一,伊藤賢司,阿部修,青木茂樹,大友邦
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 沖縄
  • Year and Date: 2010-01-28
• [Presentation] 錐体路を対象とした確率的Tractographyの臨床撮像条件における描出比較 (2009)
  • Author(s): 伊藤賢司,鈴木雄一,増谷佳孝,青木茂樹,阿部修,大友邦
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 脳梁通過線維の確率的Tractographyにおける臨床データでの描出比較 (2009)
  • Author(s): 鈴木雄一,伊藤賢司,増谷佳孝,井野賢司,佐竹芳朗,飯田恭人,矢野敬一,青木茂樹,阿部修,美馬和男,大友邦
  • Organizer: 第37回日本磁気共鳴医学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 拡散MRIに基づく確率的Tractographyにおける描出パラメータの局所調整による改善の一手法 (2009)
  • Author(s): 伊藤賢司,増谷佳孝,青木茂樹,阿部修,大友邦
  • Organizer: 第28回日本医用画像工学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-08-04
• [Presentation] diffusion Tensor Visualizer II Second Release by UTRAD/ICAL (2009)
  • Author(s): Yoshiyaka Masutani
  • Organizer: Weekend Educational Course of the International Society for Magnetic Resonance in Medicine(ISMRM) 17th Scientific Meeting & Exhibition
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2009-04-18
• [Book] Medical Imaging Intelligence and Analysis (2012)
  • Author(s): Yoshitaka Masutani, Mitsutaka Nemoto, Yukihiro Nomura, Naoto Hayashi
  • Total Pages: 159-176
  • Publisher: Machine Learning in Computer-Aided Diagnosis
• [Remarks] 招待講演(1)増谷佳孝,拡散MR画像の処理とその応用～基礎から最新動向まで～,予防医工学研究会, 2011. 10. 31,名古屋