2011 Fiscal Year Final Research Report
A safety evaluation study on dietary fat in the miniature pig. Focusing on the endocrine disrupting effect.
| Project/Area Number |
21300283
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
OHARA Naoki 金城学院大学, 薬学部, 教授 (20426422)
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| Co-Investigator(Kenkyū-buntansha) |
OKUYAMA Harumi 金城学院大学, 薬学部, 特任教授 (90080176)
YAMADA Kazuyo 金城学院大学, 薬学部, 准教授 (90080217)
NAGATA Tomoko 財団法人食品薬品安全センター, 秦野研究所, 副所長 (50426425)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脂質 / ミニブタ / 病理学 / 内分泌撹乱 / カノーラ油 |
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| Research Abstract |
Canola oil ingestion shortens the life-span of stroke-prone spontaneously hypertensive rats(SHRSP). In this study we examined the effects of canola oil ingestion in miniature pigs. Miniature pigs were given canola oil or soybean oil(as the control) at 10w/w% in diet for 18 months from weaning. The animals were then autopsied. Decreased number of germ cells in the seminiferous tubule was found. Gene expression in the testis and the adrenal gland examined by means of DNA microarray technique revealed a possible influence on the metabolism of steroid hormones.
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