The association between genetic factors and environment factors among pregnancy induced hypertension, and incidence of lifestyle-related dise ases.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390201
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Tohoku University
• Principal Investigator: IMAI Yutaka 東北大学, 大学院・薬学研究科, 教授 (40133946)
• Project Period (FY): 2009 – 2011
• Keywords: 遺伝 / 環境 / 生活習慣病 / 妊娠高血圧症候群 / 家庭血圧 / 24時間自由行動下血圧

Research Abstract

According to the number of risk associated SNPs, incidence of hypertension was increased. Parents' longevity was associated with offsprings' home blood pressure level. Subjects with relatively high aldosterone concentration and hig h salt intake had high home blood pressure and high nighttime blood pressure measured by ambulatory blood pressure monitoring. Women exposed to passive smoking had high home blood pressure and high risk for hypertension. Women with high blood pressre durin g pregnancy, with positive protein urea, had baby with small birth weight, or was heavy pre-pregnancy weight had high risk for hypertension in thirty years.

Research Products

• [Journal Article] the BOSHI Study Group. Daily serial hemodynamic data during pregnancy and seasonal (2012)
  • Author(s): Metoki H, Ohkubo T, Obara T, Akutsu K, Yamamoto M, Ishikuro M, Sakurai K, Iwama N, Katagiri M, Sugawara J, Hirose T, Sato M, Kikuya M, Yagihashi K, Matsubara Y, Yaegashi N, Mori S, Suzuki M, Imai Y
  • Journal Title: variation : the BOSHI study. Clin Exp Hypertens Volume: (In press)
  • DOI: DOI:10.3109/10641963.2012.681086
  • Peer Reviewed
• [Journal Article] lood pressure changes during pregnancy (2012)
  • Author(s): Ishikuro M, Obara T, Metoki H, Ohkubo T, Yaegashi N, Kuriyama S, Imai Y.
  • Journal Title: Hypertens Res Volume: 35 Pages: 563-564
  • DOI: DOI:10.1038/hr.2012.33
  • Peer Reviewed
• [Journal Article] Predictive Value for Mortality of the Double Product at Rest Obtained by Home Blood Pressure Measurement : The Ohasama Study (2012)
  • Author(s): Inoue R, Ohkubo T, Kikuya M, Metoki H, Asayama K, Kanno A, Obara T, Hirose T, Hara A, Hoshi H, Totsune K, Satoh H, Kondo Y, Imai Y.
  • Journal Title: Am J Hypertens Volume: 25 Pages: 568-575
  • DOI: DOI:10.1038/ajh.2012.3
  • Peer Reviewed
• [Journal Article] Aldosterone-to-Renin Ratio as a Predictor of Stroke Under Conditions of High Sodium Intake : The Ohasama Study (2012)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hara A, Utsugi MT, Hashimoto T, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: Am J Hypertens Volume: (In press)
  • DOI: DOI:10.1038/ajh.2012.33
  • Peer Reviewed
• [Journal Article] Ambulatory Versus Home Versus Clinic Blood Pressure : The Association With Subclinical Cerebrovascular Diseases : The Ohasama Study (2012)
  • Author(s): Hara A, Tanaka K, Ohkubo T, Kondo T, Kikuya M, Metoki H, Hashimoto T, Satoh M, Inoue R, Asayama K, Obara T, Hirose T, Izumi S, Satoh H, Imai Y.
  • Journal Title: Hypertension Volume: 59 Pages: 22-28
  • DOI: DOI:10.1161/HYPERTENSIONAHA.111.174938
  • Peer Reviewed
• [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population : the Ohasama study (2011)
  • Author(s): Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hashimoto T, Hara A, Utsugi MT, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: J Hypertens Volume: 29 Pages: 1940-1947
  • DOI: DOI:10.1097/HJH.0b013e32834ab46a
  • Peer Reviewed
• [Journal Article] 妊娠前後における女性のサプリメント摂取BOSHI研究 (2011)
  • Author(s): 原梓、小原拓、目時弘仁、大久保孝義、川口麻衣子、佐藤友里恵、佐々木彩乃、星川美奈子、石倉一樹、佐藤倫広、村井ユリ子、眞野康成、岩崎雅弘、八木橋香津代、森滋、八重樫伸生、鈴木雅洲、今井潤
  • Journal Title: 医薬品相互作用研究 Volume: 34 Pages: 145-149
  • Peer Reviewed
• [Journal Article] Influence of adrenomedullin 2/intermedin gene polymorphism on blood pressure, renal function and silent cerebrovascular lesions in Japanese : the Ohasama study (2011)
  • Author(s): Hirose T, Totsune K, Nakashige Y, Metoki H, Kikuya M, Ohkubo T, Hara A, Satoh M, Inoue R, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi Shin-Ichi, Rakugi H, Takahashi K and Imai Y.
  • Journal Title: Hypertens Res Volume: 34 Pages: 1327-1332
  • DOI: DOI:10.1038/hr.2011.131
  • Peer Reviewed
• [Journal Article] Individual assessment of inherent arterial stiffness using nomogram and pulse wave velocity index : the Ohasama study (2011)
  • Author(s): Hatanaka R, Obara T, Watabe D, Kimura A, Hanazawa T, Ohba H, Ishikawa T, Aikawa T, Hara A, Metoki H, Asayama K, Kikuya M, Ohkubo T, Totsune K, Imai Y.
  • Journal Title: Clin Exp Hypertens Volume: 33 Pages: 147-152
  • DOI: DOI:10.3109/10641963.2010.531839
  • Peer Reviewed
• [Journal Article] Ass (2011)
  • Author(s): Hirose T, Hashimoto M, Totsune K, Metoki H, Hara A, Satoh M, Kikuya M, Ohkubo T, Asayama K, Kondo T, Kamide K, Katsuya T, Ogihara T, Izumi S, Rakugi H, Takahashi K, Imai Y.
  • Journal Title: Hypertens Resociation of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : the Ohasama study Volume: 34 Pages: 530-535
  • DOI: DOI:10.1038/hr.2010.274
  • Peer Reviewed
• [Journal Article] mbulatory blood pressure in relation to Cardiovascular Outcomes Investigators. Ambulatory blood pressure monitoring in 9357 subjects from 11 populations highlights missed opportunities for cardiovascular prevention in women (2011)
  • Author(s): Boggia J, Thijs L, Hansen TW, Li Y, Kikuya M, Bjorklund-Bodegard K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Olszanecka A, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Maestre G, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O' Brien E, Staessen JA
  • Journal Title: Hyperternsion Volume: 57 Pages: 397-405
  • DOI: DOI:10.1161/HYPERTENSIONAHA.110.156828
  • Peer Reviewed
• [Journal Article] How many measurements are needed to provide reliable information in terms of the ambulatory arterial stiffness index? The Ohasama study (2011)
  • Author(s): Kikuya M, Staessen JA, Ohkubo T, Thijs L, Asayama K, Satoh M, Hashimoto T, Hirose T, Metoki H, Obara T, Inoue R, Li Y, Dolan E, Hoshi H, Totsune K, Satoh H, Wang JG, O' Brien E, Imai Y.
  • Journal Title: Hypertens Re Volume: 34 Pages: 314-318
  • DOI: DOI:10.1038/hr.2010.240
  • Peer Reviewed
• [Journal Article] Aldosterone-to-renin ratio and home blood pressure in subjects with higher and lower sodium intake : the Ohasama Study (2011)
  • Author(s): Satoh M, Kikuya M, Hara A, Ohkubo T, Mori T, Metoki H, Utsugi MT, Hirose T, Obara T, Inoue R, Asayama K, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: Hypertens Res Volume: 34 Pages: 361-366
  • DOI: DOI:10.1038/hr.2010.240
  • Peer Reviewed
• [Journal Article] Association of Arterial Stiffness with Silent Cerebrovascular Lesions : The Ohasama Study (2011)
  • Author(s): Hatanaka R, Obara T, Watabe D, Ishikawa T, Kondo T, Ishikura K, Aikawa T, Aono Y, Hara A, Metoki H, Asayama K, Kikuya M, Mano N, Ohkubo T, Izumi SI, Imai Y.
  • Journal Title: Cerebrovasc Dis Volume: 31 Pages: 329-337
  • DOI: DOI:10.1159/000322599
  • Peer Reviewed
• [Journal Article] Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women : the Ohasama study (2010)
  • Author(s): Seki M, Inoue R, Ohkubo T, Kikuya M, Hara A, Metoki H, Hirose T, Tsubota-Utsugi M, Asayama K, Kanno A, Obara T, Hoshi H, Totsune K, Satoh H, Imai Y.
  • Journal Title: J Hypertens Volume: 28 Pages: 1814-1820
  • DOI: DOI:10.1097/HJH.0b013e32833a3911
  • Peer Reviewed
• [Journal Article] Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease : the Ohasama study (2010)
  • Author(s): Kanno A, Metoki H, Kikuya M, Terawaki H, Hara A, Hashimoto T, Asayama K, Inoue R, Shishido Y, Nakayama M, Totsune K, Ohkubo T, Imai Y.
  • Journal Title: Hypertens Res Volume: 33 Pages: 1192-1198
  • DOI: DOI:10.1038/hr.2010.139
  • Peer Reviewed
• [Journal Article] Diurnal blood pressure variation and cardiovascular prognosis in a community-based study of Ohasama, Japan (2010)
  • Author(s): Metoki H, Ohkubo T, Imai Y.
  • Journal Title: Hypertens Res Volume: 33 Pages: 652-656
  • DOI: DOI:10.1038/hr.2010.70
  • Peer Reviewed
• [Journal Article] Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-up from the Ohasama study (2010)
  • Author(s): Watanabe Y, Metoki H, Ohkubo T, Katsuya T, Tabara Y, Kikuya M, Hirose T, Sugimoto K, Asayama K, Inoue R, Hara A, Obara T, Nakura J, Kohara K, Totsune K, Ogihara T, Rakugi H, Miki T, Imai Y.
  • Journal Title: Hypertens Res Volume: 33 Pages: 129-134
  • DOI: DOI:10.1038/hr.2009.193
  • Peer Reviewed
• [Journal Article] International Database on Ambulatory Blood Pressure In Relation to Cardiovascular Outcomes Investigators. Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 individuals from 10 populations (2010)
  • Author(s): Fan HQ, Li Y, Thijs L, Hansen TW, Boggia J, Kikuya M, Bjorklund-Bodegard K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K,
  • Journal Title: J Hypertens Volume: 28 Pages: 2036-2045
  • Peer Reviewed
• [Journal Article] Relationship of dysregulation of glucose metabolism with white-coat hypertension : the Ohasama study (2010)
  • Author(s): Hosaka M, Mimura A, Asayama K, Ohkubo T, Hayashi K, Kikuya M, Sato M, Hashimoto T, Kanno A, Hara A, Obara T, Metoki H, Inoue R, Hoshi H, Satoh H, Oka Y, Imai Y.
  • Journal Title: Hypertens Res Volume: 33 Pages: 937-943
  • Peer Reviewed
• [Journal Article] Factors associated with day-by-day variability of self-measured blood pressure at home : the Ohasama study (2010)
  • Author(s): Kato T, Kikuya M, Ohkubo T, Satoh M, Hara A, Obara T, Metoki H, Asayama K, Hirose T, Inoue R, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: Am J Hypertens Volume: 23 Pages: 980-986
  • DOI: DOI:10.1038/hr.2010.114
  • Peer Reviewed
• [Journal Article] Serum magnesium, ambulatory blood pressure, and carotid artery alteration : the Ohasama study (2010)
  • Author(s): Hashimoto T, Hara A, Ohkubo T, Kikuya M, Shintani Y, Metoki H, Inoue R, Asayama K, Kanno A, Nakashita M, Terata S, Obara T, Hirose T, Hoshi H, Totsune K, Satoh H, Imai Y.
  • Journal Title: Am J Hypertens Volume: 23 Pages: 1292-1298
  • DOI: DOI:10.1038/ajh.2010.94
  • Peer Reviewed
• [Journal Article] Stroke risk in treated hypertension based on home blood pressure : the Ohasama Study (2010)
  • Author(s): Yasui D, Ohkubo T, Kikuya M, Kanno A, Hara A, Hirose T, Obara T, Metoki H, Inoue R, Totsune K, Hoshi H, Satho H, Imai Y.
  • Journal Title: Am J Hypertens Volume: 23 Pages: 508-514
  • DOI: DOI:10.1038/ajh.2010.168
  • Peer Reviewed
• [Journal Article] International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outcomes Investigators. Prognostic value of the morning blood pressure surge in 5645 subjects from 8 populations (2010)
  • Author(s): Li Y, Thijs L, Hansen TW, Kikuya M, Boggia J, Richart T, Metoki H, Ohkubo T, Torp-Pedersen C, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Sandoya E, Kawecka-Jaszcz K, Ibsen H, Imai Y, Wang J, Staessen JA
  • Journal Title: Hypertension Volume: 55 Pages: 1040-1048
  • DOI: DOI:10.1097/HJH.0b013e3283298522
  • Peer Reviewed
• [Journal Article] International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators. Prognostic value of reading-to-reading blood pressure variability over 24 hours in 8938 subjects from 11 populations (2010)
  • Author(s): Hansen TW, Thijs L, Li Y, Boggia J, Kikuya M, Bjorklund-Bodegard K, Richart T, Ohkubo T, Jeppesen J, Torp-Pedersen C, Dolan E, Kuznetsova T, Stolarz-Skrzypek K, Tikhonoff V, Malyutina S, Casiglia E, Nikitin Y, Lind L, Sandoya E, Kawecka-Jaszcz K, Imai Y, Wang J, Ibsen H, O' Brien E, Staessen JA
  • Journal Title: Hypertensio Volume: 55 Pages: 1049-1057
  • DOI: DOI:10.1161/HYPERTENSIONAHA.109.137273
  • Peer Reviewed
• [Journal Article] Stroke risk of blood pressure indices determined by home blood pressure measurement. The Ohasama Study (2009)
  • Author(s): Inoue R, Ohkubo T, Kikuya M, Metoki H, Asayama K, Kanno A, Obara T, Hirose T, Hara A, Totsune K, Satoh H, Kondo Y, Imai Y.
  • Journal Title: Stroke Volume: 40 Pages: 2859-2861
  • DOI: DOI:10.1038/ajh.2010.15
  • Peer Reviewed
• [Journal Article] Association of (pro)renin receptor gene polymorphism with blood pressure in Japanese men : the Ohasama study (2009)
  • Author(s): Hirose T, Hashimoto M, Totsune K, Metoki H, Asayama K, Kikuya M, Sugimoto K, Katsuya T, Ohkubo T, Hashimoto J, Rakugi H, Takahashi K, Imai Y.
  • Journal Title: Am J Hypertens Volume: 22 Pages: 294-299
  • DOI: DOI:10.1161/
  • Peer Reviewed
• [Journal Article] Detection of silent cerebrovascular lesions in subjects with"masked" and"white-coat" hypertension by home blood pressure measurement : The Ohasama Study (2009)
  • Author(s): Hara A, Ohkubo T, Kondo T, Kikuya M, Aono Yoko, Hanawa S, Shioda K, Miyamoto S, Obara T, Metoki H, Inoue R, Asayama K, Hirose T, Totsune K, Hoshi H, Shin-Ichi Izumi, Hiroshi Satoh, and Imai Y.
  • Journal Title: J Hypertens Volume: 27 Pages: 1049-1055
  • DOI: DOI:10.1038/ajh.2008.357
  • Peer Reviewed
• [Journal Article] Detection of midpregnancy fall in blood pressure by out-of-office monitoring (2009)
  • Author(s): Metoki H, Ohkubo T, Sato Y, Kawaguchi M, Nishimura M, Watanabe Y, Imai Y.
  • Journal Title: Hypertension Volume: 53 Pages: 12-13
  • DOI: DOI:10.1161/HYPERTENSIONAHA.109.140798
  • Peer Reviewed
• [Journal Article] Influence of alcohol intake on circadian blood pressure variation in Japanese men : the Ohasama study (2009)
  • Author(s): Nakashita M, Ohkubo T, Hara A, Metoki H, Kikuya M, Hirose T, Tsubota-Utsugi M, Asayama K, Inoue R, Kanno A, Obara T, Hoshi H, Totsune K, Satoh H, Imai Y.
  • Journal Title: Am J Hypertens Volume: 22 Pages: 1171-1176
  • DOI: DOI:10.1038/ajh.2009.160
  • Peer Reviewed
• [Journal Article] Parental longevity and offspring's home blood pressure : the Ohasama study (2009)
  • Author(s): Watanabe Y, Metoki H, Ohkubo T, Hirose T, Kikuya M, Asayama K, Inoue R, Hara A, Obara Ta, Hoshi H, Totsune K, Imai Y.
  • Journal Title: J Hypertens Volume: 27 Pages: 272-277
  • DOI: DOI:10.1097/HJH.0b013e328332fa78
  • Peer Reviewed
• [Journal Article] The association between masked hypertension and waist circumference as obesity-related antheropometric index for metabolic syndrome : the Ohasama study (2009)
  • Author(s): Asayama K, Sato A, Ohkubo T, Mimura A, Hayashi K, Kikuya M, Yasui D, Kanno A, Hara A, Hirose T, Obara T, Metoki H, Inoue R, Hoshi H, Satoh H, Imai Y.
  • Journal Title: Hypertens Res Volume: 32 Pages: 438-443
  • DOI: DOI:10.1038/hr.2009.37
  • Peer Reviewed
• [Journal Article] Repeated evening home blood pressure measurement improves prognostic significance for stroke : a 12-year follow-up of the Ohasama study (2009)
  • Author(s): Asayama K, Ohkubo T, Hara A, Hirose T, Yasui D, Obara T, Metoki H, Inoue R, Kikuya M, Totsune K, Hoshi H, Satoh H, Imai Y.
  • Journal Title: Blood Press Monit Volume: 14 Pages: 93-98
  • DOI: DOI:10.1097/MBP.0b013e32832a9d91
  • Peer Reviewed
• [Presentation] 妊娠中Pulse Wave Velocity(PWV)と妊娠高血圧症候群(PIH)及び家庭血圧推移との関連:BOSHI研究 (2011)
  • Author(s): 阿久津好美、今井潤, 他
  • Organizer: 第32回日本妊娠高血圧学会
  • Place of Presentation: 金沢
  • Year and Date: 2011-10-21
• [Presentation] Tissue inhibitor of metalloproteinase 3(TIMP-3)遺伝子プロモーター領域の一塩基多型は血圧値と関連する (2011)
  • Author(s): 小黒亮輔、今井潤, 他
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-21
• [Presentation] 24時間自由行動下血圧・家庭血圧と脳血管障害 (2011)
  • Author(s): 目時弘仁、今井潤, 他
  • Organizer: 第32回日本妊娠高血圧学会
  • Place of Presentation: 金沢
  • Year and Date: 2011-10-21
• [Presentation] 妊娠期間中血圧推移と妊婦の母親の妊娠期間中血圧レベルとの関連:BOSHI研究 (2011)
  • Author(s): 目時弘仁、今井潤, 他
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-20
• [Presentation] 妊娠期間中の収縮期血圧・心拍数・ダブルプロダクト・ショックインデックス値の推移と季節変動:BOSHI研究 (2011)
  • Author(s): 目時弘仁、今井潤, 他
  • Organizer: 第13回時間循環血圧管理研究
  • Place of Presentation: 東京
  • Year and Date: 2011-07-05
• [Presentation] 喫煙・受動喫煙と妊娠期間中の血圧推移:BOSHI研究 (2010)
  • Author(s): 目時弘仁、今井潤, 他
  • Organizer: 第31回日本妊娠高血圧学会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-16
• [Presentation] 家庭血圧によるHome Arterial Sti￢ness Index (HASI)の脳卒中発症予測能 (2010)
  • Author(s): 東京 7. 菊谷昌浩、今井潤、(他)
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-16
• [Presentation] アドレノメデュリン2/インターメジン遺伝子多型と血圧、腎機能、無症候性脳血管障害との関連の検討:大迫研究 (2010)
  • Author(s): 廣瀬卓男、今井潤, 他
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-15
• [Presentation] 受動喫煙の家庭血圧に対する影響:大迫研究 (2010)
  • Author(s): 関真美、今井潤, 他
  • Organizer: 第33回日本高血圧学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-10-15
• [Presentation] Smoking, passive smoking and home blood pressure values during pregnancy : the BOSHI study (2010)
  • Author(s): Metoki H, et al. and Imai Y.
  • Organizer: 第17回国際妊娠高血圧学会
  • Place of Presentation: メルボルン
  • Year and Date: 2010-10-06
• [Presentation] Decreased mid pregnancy fall in home blood pressure in relation to insulin resistance : the BOSHI study (2010)
  • Author(s): Kawaguchi M, et al. and Imai Y.
  • Organizer: 第20回欧州高血圧会議
  • Place of Presentation: オスロ
  • Year and Date: 2010-06-19
• [Book] 家庭血圧測定とその有用性産婦人科治療 (2011)
  • Author(s): 目時弘仁、八重樫伸生、今井潤
  • Total Pages: 82-87
  • Publisher: 永井書店
• [Book] ゲノム疫学の研究5. 大迫研究家庭血圧の重要性を証明-遺伝子解析の結果-BIO Clinica (2010)
  • Author(s): 目時弘仁、今井潤
  • Total Pages: 34-38
  • Publisher: 北隆館
• [Book] 臨床高血圧レビュー (2009)
  • Author(s): 今井潤、Therapeutic Research
  • Total Pages: 1707-1821
  • Publisher: ライフサイエンス出版
• [Book] 腎と透析:【CKDのすべて】日本のコホート研究大迫研究 (2009)
  • Author(s): 寺脇博之、今井潤, 他
  • Total Pages: 52-55
  • Publisher: 東京医学社
• [Book] 治療学:【高血圧日常診療に十分に配慮した新ガイドライン】リスク評価と血圧管理計画(解説/特集) (2009)
  • Author(s): 今井潤, 他
  • Total Pages: 489-492
  • Publisher: ライフサイエンス出版