Development of the bioactive titanium alloy equipped with an osteoinductive property

2011 Fiscal Year Final Research Report

• Project/Area Number: 21390523
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tohoku University
• Principal Investigator: TAKADA Yukyo 東北大学, 大学院・歯学研究科, 准教授 (10206766)
• Co-Investigator(Kenkyū-buntansha): KANETAKA Hiroyasu 東北大学, 大学院・歯学研究科, 准教授 (50292222) ; SHIMIZU Yoshinaka 東北大学, 大学院・歯学研究科, 助教 (30302152)
• Co-Investigator(Renkei-kenkyūsha): KIKUCHI Masafumi 鹿児島大学, 大学院・医歯学総合研究科, 教授 (50250791) ; TAKAHASHI Masatoshi 東北大学, 大学院・歯学研究科, 助教 (50400255)
• Project Period (FY): 2009 – 2011
• Keywords: チタン合金 / Mg 合金 / 骨誘導 / Mg イオン / 細胞培養 / ALP / Ti-Mg 合金 / 骨形成

Research Abstract

In this research program, we tried to develop the titanium alloy equipped with an osteoinductive property derived from sustained delivery of Mg ions. Although the Ti-Mg solid solution with the sustained delivery of Mg ions could not be obtained, under the conditions of Mg ions, the amount of DNAs and cell growth were as same as those of controls, and the ALP activity values significantly increased. Since the vascular proliferation was observed in the vascular endothelial cells and the lumen formation, we concluded that it is preferable to develop the Ti-Mg solid solution as anew functional material.