2011 Fiscal Year Final Research Report
Purinergic circuit formation at the critical period in the mouse retina
| Project/Area Number |
21500373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Keio University |
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Principal Investigator |
KANEDA Makoto 慶應義塾大学, 医学部, 准教授 (30214480)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Akimichi 畿央大学, 健康科学部, 教授 (00051491)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経 / 筋肉生理学 |
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| Research Abstract |
Circuit formation of visual system occurs before the critical period and did not show any plastic change to visual experience. Since circuit formation of P2X2-purinoceptor occurs in the critical period, we examined whether the circuit formation of P2X2-purinoceptor shows plastic change to visual experience in the mouse retina. We found that the circuit formation of P2X2-purinoceptors did not show any plastic change to visual experience, suggesting the presence of intrinsically programmed process.
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Research Products
(15 results)
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[Journal Article] Deletions of SCN1A 5' genomic region with promoter activity in Dravet syndrome2010
Author(s)
Nakayama, T., Ogiwara I., Ito K., Kaneda M., Mazaki E., Osaka H., Ohtani H., Inoue Y., Fujiwara T., Uematsu M., Haginoya K., Tsuchiya S., Yamakawa K
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Journal Title
Hum. Mutat
Volume: 31
Pages: 820-829
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