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2011 Fiscal Year Final Research Report

Drug development using accelerated aging model

Research Project

  • PDF
Project/Area Number 21590289
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionJichi Medical University

Principal Investigator

KOSHIMIZU Taka-aki  自治医科大学, 医学部, 准教授 (20392491)

Co-Investigator(Renkei-kenkyūsha) TSUCHIYA Hiroyoshi  自治医科大学, 医学部, 助教 (80508755)
Project Period (FY) 2009 – 2011
Keywordsバゾプレッシン / リポフスチン / 副腎皮質 / ノックアウトマウス
Research Abstract

Vasopressin is known to promote cellular growth and protein synthesis in adrenocortical and other cell types. We examined the role of V1a receptor in steroid secretion and cellular aging in adrenal cortex. In adrenocortical cell line, vasopressin promoted glucocorticoid secretion when applied alone or together with adrenocortical hormone. This study also found that V1a knockout mouse is an excellent model for studying aging in adrenocortical cells.

  • Research Products

    (2 results)

All 2012

All Journal Article (2 results)

  • [Journal Article] The roles of V1a vasopressin receptors in blood pressure homeostasis : a review of studies on V1a receptor knockout mice2012

    • Author(s)
      Fujiwara Y, Tanoue A, Tsujimoto G, and Koshimizu TA.
    • Journal Title

      Clin Exp Nephrol

      Volume: 16 Pages: 30-34

  • [Journal Article] Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human2012

    • Author(s)
      Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Korner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, and Froguel P.
    • Journal Title

      Nature

      Volume: 483 Pages: 350-354

URL: 

Published: 2013-07-31  

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