2011 Fiscal Year Final Research Report
Resistance of cancer stem cells to p53-induced cell death and its mechanism
| Project/Area Number |
21590438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
TAKAHASHI Rei 同志社女子大学, 薬学部, 教授 (60144565)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遺伝子 / バイオテクノロジー / 病理学 / 癌 / 細胞 / 組織 |
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| Research Abstract |
One of the therapeutic measures against cancer is to cause apoptotic cell death introduced by inducing p53 overexpression. In this study, we constructed a special breast cancer cell, by which apoptosis-resistant cells are analyzed. These apoptosis-resistant cancer cells were found to express. The ALDH1 gene that is considered as a marker of the breast cancer stem cell. Development of new drug can be promoted through the detail analyzes of the cancer stem cell population.
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