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2011 Fiscal Year Final Research Report

Studies on the mechanism to gain monocyte chemotactic capacity of ribosomal protein S19 and its role in coagulum resorption.

Research Project

  • PDF
Project/Area Number 21590441
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKumamoto University

Principal Investigator

YAMAMOTO Tetsuro  熊本大学, 大学院・生命科学研究部, 教授 (60112405)

Project Period (FY) 2009 – 2011
Keywordsリボソームタンパク質S19 / プロトロンビン / 血液凝固反応 / 凝固XIII因子 / 血小板 / 線溶
Research Abstract

In the present research, we have revealed that ribosomal protein S19(RP S19) present in normal blood plasma is covalently dimerized by activated factor XIII on the activated platelet surface and gains monocyte chemotactic capacity during blood coagulation process, that the RP S19 dimer recruits monocytes to the coagulum resulting in cellular fibrinolytic absorption of the coagulum, and that monocytotic state of peripheral blood enhance the coagulum resorption process.

  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (9 results) Book (1 results)

  • [Journal Article] Ribosomal protein S19 is present in plasma as a complex with prothrombin2011

    • Author(s)
      Nishiura, H., Tanase, S., Tsujita, K., Sugiyama, S., Ogawa, ・H., Nakagaki, T., Semba, U., and Yamamoto, T.
    • Journal Title

      Eur. J. Haematol.

      Volume: 86 Pages: 436-441

    • DOI

      DOI:10.1111/j.1600-0609.2011.01585.x

    • Peer Reviewed
  • [Journal Article] Role of ribosomal protein S19-like plasma protein in blood coagulum resorption2010

    • Author(s)
      Ota, Y., Chen, J., Shin, M., Nishiura, H., Tokita, K., Shinohara, M., Yamamoto, T.
    • Journal Title

      Exp. Mol. Pathol.

      Volume: 90 Pages: 19-28

    • Peer Reviewed
  • [Journal Article] Base of molecular mimicry between human ribosomal protein S19 dimer and human C5a anaphylatoxin2010

    • Author(s)
      Nishiura, H., Chen, J., Ota, Y., Semba, U., Higuchi, H., Nakashima, T., Yamamoto, T.
    • Journal Title

      Int. Immunopharmacol.

      Volume: 10(12) Pages: 1541-1547

    • Peer Reviewed
  • [Journal Article] Inter-conversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5a receptor by a single amino acid substitution2010

    • Author(s)
      Jia, N., Semba, U., Nishiura, H., Kuniyasu, A., Nsiama, T. K., Nishino, N., and Yamamoto, T.
    • Journal Title

      J. Leukocyt. Biol.

      Volume: 87 Pages: 965-975

    • Peer Reviewed
  • [Journal Article] A Plasma Protein Indistinguishable from Ribosomal Protein S19 : Conversion to a Monocyte Chemotactic Factor by a Factor XIIIa-Catalyzed Reaction on Activated Platelet Membrane Phosphatidylserine in Association with Blood Coagulation2010

    • Author(s)
      Semba, U., Chen, J., Ota, Y., Jia, N., Arima, H., Nishiura, H., and Yamamoto, T.
    • Journal Title

      Am. J. Pathol.

      Volume: 176 Pages: 542-1551

    • Peer Reviewed
  • [Journal Article] Pro-and anti-apoptotic dual functions of the C5a receptor : Involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase2009

    • Author(s)
      Nishiura, H., Nonaka, H., Revollo, I., Semba, U., Li, Y., Irie, A., Harada, K., Kehrl, J. H. and Yamamoto, T.
    • Journal Title

      Lab. Invest.

      Volume: 89 Pages: 676-694

    • Peer Reviewed
  • [Presentation] Ribosomal protein S19-prothrombin complex in plasma and its role in coagulum resorption2011

    • Author(s)
      Umeko Semba, Hiroshi Nishiura, Tetsuro Yamamoto
    • Organizer
      第36回日本微小循環学会総会
    • Place of Presentation
      愛知県・名古屋市立大学大ホール
    • Year and Date
      2011-02-11
  • [Presentation] A molecular mimicry basis on the two-step binding structure to the C5a receptor between ribosomal protein S19 homodimer cross-linked by transglutaminase and C5a anaphylatoxin2010

    • Author(s)
      Hiroshi Nishiura, Tetsuro Yamamoto
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      兵庫県・神戸ポートアイランド
    • Year and Date
      2010-12-10
  • [Presentation] Maintenance of ribosomal protein S19 in plasma by complex formation with prothrombin2010

    • Author(s)
      Umeko Semba, Hiroshi Nishiura, Sumio Tanase, Tetsuro Yamamoto
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      兵庫県・神戸ポートアイランド
    • Year and Date
      2010-12-10
  • [Presentation] Conversion of a ribosomal protein S19-like plasma protein to a monocyte chemotactic factor on activated platelets during blood coagulation2010

    • Author(s)
      Tetsuro Yamamoto
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      兵庫県・神戸ポートアイランド
    • Year and Date
      2010-12-09
  • [Presentation] 第2の補体C5aリセプターリガンドにより活性化するヒト肥満細胞株HMC-1内の新たなGi蛋白質依存性p38MAPK-TRPM経路2009

    • Author(s)
      西浦弘志, 山本哲郎
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県・神戸ポートアイランド
    • Year and Date
      2009-10-24
  • [Presentation] S19リボソームタンパク質の凝固XIIIa因子による架橋二量体化とその凝血塊吸収における役割2009

    • Author(s)
      山本哲郎
    • Organizer
      第82回生化学会大会
    • Place of Presentation
      兵庫県・神戸ポートアイランド
    • Year and Date
      2009-10-23
  • [Presentation] 血漿に含まれるS19リボソームタンパク質様分子の血液凝固に伴う架橋二量体化機構2009

    • Author(s)
      千場梅子, 甚俊, 太田宜彦, 西浦弘志, 山本哲郎
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県・神戸ポートアイランド
    • Year and Date
      2009-10-22
  • [Presentation] 血漿のS19リボソームタンパク質様分子の二量体化と単球C5aレセプターの凝血塊吸収における役割2009

    • Author(s)
      太田宜彦, 千場梅子, 甚俊, 西浦弘志, 山本哲郎
    • Organizer
      第46回補体シンポジウム
    • Place of Presentation
      福岡県・九州大学西新プラザ大会議室
    • Year and Date
      2009-08-21
  • [Presentation] 血漿中のS19リボソームタンパク質様分子の血液凝固に伴う単球走化活性の獲得と凝血塊除去における役割2009

    • Author(s)
      太田宜彦, 山本哲郎
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都府・国立京都国際会館
    • Year and Date
      2009-05-01
  • [Book] Extraribosomal functions of ribosomal protein S19 In Ribosomal Proteins and Protein Engineering : Design, Selection and Applications(Valter Ortendhal, Hjalmar Salchow eds.)2010

    • Author(s)
      T. Yamamoto and H. Nishiura
    • Total Pages
      21-39
    • Publisher
      Nova Scientific Publishers

URL: 

Published: 2013-07-31  

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