Cerebral arteriolar MRI as an etiological marker for stroke and cognitive impairment

2013 Fiscal Year Final Research Report

• Project/Area Number: 21591112
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: HIROKI Masahiko 京都大学, 医学(系)研究科(研究院), 非常勤講師 (30456884)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Naoto 茨城県立医療大学, 保健医療学部, 教授 (40239900)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Keywords: 脳神経疾患 / 循環器・高血圧

Research Abstract

One hundred three subjects were registered in this study until March 31, 2014. Hypertension was found in 45. It was shown that linear hyperintensities in the cerebral white matter (LH-WM) was negatively correlated with volume and positively correlated with number of silent lacunar infarcts. Linear hyperintensities in the basal ganglia (LH-BG) was positively correlated with number of lacunar infarcts. Both LHs was not correlated with results of neuropsychological tests. It is suggested that LH-WM and LH-BG have relationship with aging and brain volume. Since silent lacunar infarct has a link with symptomatic stroke and cognitive impairment, both LHs have a potential of clinical significance. Further analyses needs to include results of serum biomarkers, to use multivariate statistical method. We also need to add number of subjects for statistical power.

Research Products

• [Journal Article] Higher gravidity and parity are associated with increased prevalence of metabolic syndrome among rural Bangladeshi women (2013)
  • Author(s): Akter S, Jesmin S, Rahman MM, Islam MM, Khatun MT, Yamaguchi N, Akashi H, Mizutani T
  • Journal Title: PLoS One Volume: 8(8) Pages: e68319
  • DOI: 10.1371/journal.pone.0068319
  • Peer Reviewed
• [Journal Article] Metabolic syndrome among pre- and post-menopausal rural women in Bangladesh : result from a population-based study (2013)
  • Author(s): Jesmin S, Islam AS, Akter S, Islam MM, Sultana SN, Yamaguchi N, Okazaki O, Moroi M, Hiroe M, Kimura S, Watanabe T, Saturo K, Mizutani T
  • Journal Title: BMC Res Notes Volume: 6 Pages: 157
  • Peer Reviewed
• [Journal Article] Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome. Findings from a study conducted in rural Bangladeshi women (2013)
  • Author(s): Jesmin S1, Akter S, Rahman MM, Islam MM, Islam AM, Sultana SN, Mowa CN, Yamaguchi N, Okazaki O, Satoru K, Kimura S, Hiroe M, Mizutani T, Moroi M
  • Journal Title: Thromb Haemost Volume: 109 Pages: 696-705
  • DOI: 10.1160/TH12-09-0654
• [Presentation] Assessment of circulatory endothelin-1 level among pre- and post-menopausal rural women in Bangladesh : result from a population-based study (2013)
  • Author(s): Khatun T, Jesmin S, Yamaguchi N
  • Organizer: Thirteenth International Conference on Endothelin
  • Place of Presentation: Tokyo
  • Year and Date: 20130900
• [Presentation] Potential amelioration of upregulated renal HIF1alpha-Endothelin 1 system through landiolol hydrochloride in a rat model of endotoxemia : a possible linkage to the increased renal vascular resistance based on renal microcirculation alteration in sepsis (2013)
  • Author(s): Ogura Y, Jesmin S, Yamaguchi N
  • Organizer: Thirteenth International Conference on Endothelin
  • Place of Presentation: Tokyo
  • Year and Date: 20130900
• [Presentation] シルジニピン(Cil)による糖尿病性腎症における抗蛋白尿効果 (2013)
  • Author(s): 山木万里郎、山口直人
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 20130500
• [Presentation] 99mTc-ECD SPECT法による全脳平均血流測定値と慢性腎臓病関連臨床指標との関連 (2013)
  • Author(s): 山口直人、廣木昌彦
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 20130500
• [Book] Chapter 12. Development of Therapeutic Strategy to Restore Coronary Microcirculation and VEGF Signaling Cascade in Diabetes Mellitus. A holistic approach to diagnosis and treatment (2014)
  • Author(s): Jesmin S, Rahman A, Mamun AA, Yamaguchi N
  • Publisher: Apple Academic Press