2011 Fiscal Year Final Research Report
Epigenetic control of gene expression associated with adult diseases due to fetal nutritional factors
| Project/Area Number |
21591409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
MUROTSUKI Jun 東北大学, 大学院・医学系研究科, 非常勤講師 (50239555)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Kazuyo 東北大学, 大学院・医学系研究科, 非常勤講師 (70375020)
ARAKI Yoshihiko 順天堂大学, 環境医学研究所, 准教授 (70250933)
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| Project Period (FY) |
2009 – 2011
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| Keywords | DOHaD仮説 / 低タンパク食 / メチル化 / エピジェネティクス / 妊娠マウス |
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| Research Abstract |
One likely mechanism of the developmental origins hypothesis is via early nutritional influences on epigenetic gene modification consisting of the presence of a methyl group on the carbon 5 of a cytosine residue. We have tested the hypothesis that maternal low-protein diet altered epigenetic regulation of specific gene of the offspring. Hepatic Oct-4 or Sphk-1 methylation pattern of the genomic DNA is specific in low-protein diet group. Aberrant Oct-4 and Sphk-1 gene expression may cause perturbations in cell differentiation. We suggest that the epigenetic mechanism consisting of DNA methylation underlies the fetal programming theory.
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