Investigation of sensory processing deficits in schizophrenia using mismatch response

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591511
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: MOTOMURA Eishi 三重大学, 医学部附属病院, 講師 (10324534)
• Co-Investigator(Kenkyū-buntansha): INUI Koji 生理学研究所, 総合生理研究系, 准教授 (70262996) ; MAEDA Masayuki 三重大学, 医学部附属病院, 講師 (70219278)
• Project Period (FY): 2009 – 2011
• Keywords: 自動注意処理 / 上側頭回 / 統合失調症

Research Abstract

Rapid detection of changes in the surrounding environment is one of the most important features of sensory processing. In this study, we aimed to investigate the auditory change detection system and clarify the auditory processing deficit in schizophrenia using N1 and N1m responses. The main findings of this study were as follows : 1) The change-related response was related to sensory memory and mainly originated from the superior temporal gyrus(STG). 2) The generators of N1m elicited by three types of an abrupt changes in sound stimuli(sound location, sound frequency and sound pressure) were estimated in a similar area in the auditory cortex, probably STG. 3) The magnitude of change-related brain activity in patients with chronic schizophrenia was significantly lower than that in controls regardless of the type of abrupt change in a continuous sound. In conclusion, STG works as a sensory gate that opens toward a new event. Moreover, higher-order processing deficits exist in schizophrenia.

Research Products

• [Journal Article] Electroencephalographic dipole source modeling of frontal intermittent rhythmic delta activity (2012)
  • Author(s): Motomura E, Inui K, Ohoyama K, Nishimura Y, Nakagawa M, Maeda M, Matsushima N, Ushiro K, Suzuki D, Kakigi R, Okada M
  • Journal Title: Neuropsychobiol Volume: 65 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Memory-based pre-attentive auditory N1 elicited by sound movement
  • Author(s): Ohoyama K, Motomura E, Inui K, Nishihara M, Otsuru N, Oi M, Kakigi R, Okada M
  • Journal Title: Neurosci Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Source Localization of posterior Slow waves of Youth by Dipole Modeling
  • Author(s): Ohoyama K, Motomura E, Inui K, Nishimura Y, Ushiro K, Matushima N, Maeda M, Tanii H, Suzuki D, Hamanaka K, Kakigi R, Okada M
  • Journal Title: Psychiatry Clin Neurosci Volume: (in press)
  • Peer Reviewed
• [Presentation] 境界領域脳波の再考:若年性後頭部徐波とFIRDAの信号源解析 (2010)
  • Author(s): 元村英史、乾幸二、大山慶子、松本卓也、岡田元宏
  • Organizer: 日本総合病院精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 慢性統合失調症での聴覚変化探知反応:事象関連電位研究 (2010)
  • Author(s): 大山慶子、元村英史、乾幸二、浦川智和、中川雅紀、柿木隆介、岡田元宏
  • Organizer: 日本生物学的精神医学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-10-09
• [Presentation] Frontal intermittent rhythmic delta activity(FIRDA)の発生機序について-双極子追跡法を用いて- (2009)
  • Author(s): 元村英史、大山慶子、中川雅紀、鈴木大、岡田元宏
  • Organizer: 三重てんかん研究会
  • Place of Presentation: 津
  • Year and Date: 2009-09-12